1p0z

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[[Image:1p0z.gif|left|200px]]<br /><applet load="1p0z" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1p0z.gif|left|200px]]
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caption="1p0z, resolution 1.60&Aring;" />
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'''Sensor Kinase CitA binding domain'''<br />
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{{Structure
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|PDB= 1p0z |SIZE=350|CAPTION= <scene name='initialview01'>1p0z</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=MO7:HEPTAMOLYBDATE'>MO7</scene> and <scene name='pdbligand=OMO:MO(VI)(=O)(OH)2 CLUSTER'>OMO</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3]
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|GENE= CITA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 Klebsiella pneumoniae])
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}}
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'''Sensor Kinase CitA binding domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1P0Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae] with <scene name='pdbligand=FLC:'>FLC</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=MO7:'>MO7</scene> and <scene name='pdbligand=OMO:'>OMO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0Z OCA].
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1P0Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P0Z OCA].
==Reference==
==Reference==
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The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12867417 12867417]
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The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12867417 12867417]
[[Category: Histidine kinase]]
[[Category: Histidine kinase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:18:19 2008''

Revision as of 11:18, 20 March 2008

Image:1p0z.gif


PDB ID 1p0z

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands: , , and
Gene: CITA (Klebsiella pneumoniae)
Activity: Histidine kinase, with EC number 2.7.13.3
Coordinates: save as pdb, mmCIF, xml



Sensor Kinase CitA binding domain


Overview

The integral membrane sensor kinase CitA of Klebsiella pneumoniae is part of a two-component signal transduction system that regulates the transport and metabolism of citrate in response to its environmental concentration. Two-component systems are widely used by bacteria for such adaptive processes, but the stereochemistry of periplasmic ligand binding and the mechanism of signal transduction across the membrane remain poorly understood. The crystal structure of the CitAP periplasmic sensor domain in complex with citrate reveals a PAS fold, a versatile ligand-binding structural motif that has not previously been observed outside the cytoplasm or implicated in the transduction of conformational signals across the membrane. Citrate is bound in a pocket that is shared among many PAS domains but that shows structural variation according to the nature of the bound ligand. In CitAP, some of the citrate contact residues are located in the final strand of the central beta-sheet, which is connected to the C-terminal transmembrane helix. These secondary structure elements thus provide a potential conformational link between the periplasmic ligand binding site and the cytoplasmic signaling domains of the receptor.

About this Structure

1P0Z is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain., Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR, J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. PMID:12867417

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