2fd4
From Proteopedia
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| - | + | ==Crystal Structure of AvrPtoB (436-553)== | |
| - | + | <StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses. | ||
| - | + | A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.,Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:16373536<ref>PMID:16373536</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Avirulence protein|Avirulence protein]] | *[[Avirulence protein|Avirulence protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Pseudomonas syringae]] | [[Category: Pseudomonas syringae]] | ||
| - | [[Category: Janjusevic, R | + | [[Category: Janjusevic, R]] |
| - | [[Category: Stebbins, C E | + | [[Category: Stebbins, C E]] |
[[Category: Avrptob]] | [[Category: Avrptob]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 13:47, 17 December 2014
Crystal Structure of AvrPtoB (436-553)
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