3eyk

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{{STRUCTURE_3eyk| PDB=3eyk | SCENE= }}
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==Structure of Influenza Haemagglutinin in complex with an inhibitor of membrane fusion==
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===Structure of Influenza Haemagglutinin in complex with an inhibitor of membrane fusion===
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<StructureSection load='3eyk' size='340' side='right' caption='[[3eyk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19004788}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3eyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EYK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EYK:2-TERT-BUTYLBENZENE-1,4-DIOL'>EYK</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eyj|3eyj]], [[3eym|3eym]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3eyk RCSB], [http://www.ebi.ac.uk/pdbsum/3eyk PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/3eyk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The influenza surface glycoprotein hemagglutinin (HA) is a potential target for antiviral drugs because of its key roles in the initial stages of infection: receptor binding and the fusion of virus and cell membranes. The structure of HA in complex with a known inhibitor of membrane fusion and virus infectivity, tert-butyl hydroquinone (TBHQ), shows that the inhibitor binds in a hydrophobic pocket formed at an interface between HA monomers. Occupation of this site by TBHQ stabilizes the neutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the conformational rearrangements required for membrane fusion. The nature of the binding site suggests routes for the chemical modification of TBHQ that could lead to the development of more potent inhibitors of membrane fusion and potential anti-influenza drugs.
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==About this Structure==
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Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion.,Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. Epub 2008 Nov 12. PMID:19004788<ref>PMID:19004788</ref>
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[[3eyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EYK OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin|Hemagglutinin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019004788</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
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[[Category: Gamblin, S J.]]
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[[Category: Gamblin, S J]]
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[[Category: Kerry, P S.]]
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[[Category: Kerry, P S]]
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[[Category: Martin, S R.]]
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[[Category: Martin, S R]]
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[[Category: Russell, R J.]]
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[[Category: Russell, R J]]
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[[Category: Skehel, J J.]]
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[[Category: Skehel, J J]]
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[[Category: Steinhauer, D A.]]
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[[Category: Steinhauer, D A]]
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[[Category: Stevens, D J.]]
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[[Category: Stevens, D J]]
[[Category: Envelope protein]]
[[Category: Envelope protein]]
[[Category: Fusion protein]]
[[Category: Fusion protein]]

Revision as of 13:49, 17 December 2014

Structure of Influenza Haemagglutinin in complex with an inhibitor of membrane fusion

3eyk, resolution 2.50Å

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