2qwy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_2qwy| PDB=2qwy | SCENE= }}
+
==SAM-II riboswitch bound to S-adenosylmethionine==
-
===SAM-II riboswitch bound to S-adenosylmethionine===
+
<StructureSection load='2qwy' size='340' side='right' caption='[[2qwy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_18204466}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QWY FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CS:CESIUM+ION'>CS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qwy RCSB], [http://www.ebi.ac.uk/pdbsum/2qwy PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In bacteria, numerous genes harbor regulatory elements in the 5' untranslated regions of their mRNA, termed riboswitches, which control gene expression by binding small-molecule metabolites. These sequences influence the secondary and tertiary structure of the RNA in a ligand-dependent manner, thereby directing its transcription or translation. The crystal structure of an S-adenosylmethionine-responsive riboswitch found predominantly in proteobacteria, SAM-II, has been solved to reveal a second means by which RNA interacts with this important cellular metabolite. Notably, this is the first structure of a complete riboswitch containing all sequences associated with both the ligand binding aptamer domain and the regulatory expression platform. Chemical probing of this RNA in the absence and presence of ligand shows how the structure changes in response to S-adenosylmethionine to sequester the ribosomal binding site and affect translational gene regulation.
-
==About this Structure==
+
Structure of the SAM-II riboswitch bound to S-adenosylmethionine.,Gilbert SD, Rambo RP, Van Tyne D, Batey RT Nat Struct Mol Biol. 2008 Feb;15(2):177-82. Epub 2008 Jan 20. PMID:18204466<ref>PMID:18204466</ref>
-
[[2qwy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QWY OCA].
+
 
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
==See Also==
==See Also==
*[[Riboswitch|Riboswitch]]
*[[Riboswitch|Riboswitch]]
-
[[Category: Batey, R T.]]
+
== References ==
-
[[Category: Gilbert, S D.]]
+
<references/>
-
[[Category: Rambo, R P.]]
+
__TOC__
-
[[Category: Tyne, D Van.]]
+
</StructureSection>
 +
[[Category: Batey, R T]]
 +
[[Category: Gilbert, S D]]
 +
[[Category: Rambo, R P]]
 +
[[Category: Tyne, D Van]]
[[Category: Adomet]]
[[Category: Adomet]]
[[Category: Base triple]]
[[Category: Base triple]]

Revision as of 13:49, 17 December 2014

SAM-II riboswitch bound to S-adenosylmethionine

2qwy, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qwy"
Personal tools