3g6e

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{{Large structure}}
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==Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit==
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{{STRUCTURE_3g6e| PDB=3g6e | SCENE= }}
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<StructureSection load='3g6e' size='340' side='right' caption='[[3g6e]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_19362093}}
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<table><tr><td colspan='2'>[[3g6e]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G6E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HMT:(3BETA)-O~3~-[(2R)-2,6-DIHYDROXY-2-(2-METHOXY-2-OXOETHYL)-6-METHYLHEPTANOYL]CEPHALOTAXINE'>HMT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g4s|3g4s]], [[3g71|3g71]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g6e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g6e RCSB], [http://www.ebi.ac.uk/pdbsum/3g6e PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g6/3g6e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Structures have been obtained for the complexes that tiamulin, homoharringtonine, and bruceantin form with the large ribosomal subunit of Haloarcula marismortui at resolutions ranging from 2.65 to 3.2 A. They show that all these inhibitors block protein synthesis by competing with the amino acid side chains of incoming aminoacyl-tRNAs for binding in the A-site cleft in the peptidyl-transferase center, which is universally conserved. In addition, these structures support the hypothesis that the species specificity exhibited by the A-site cleft inhibitors is determined by the interactions they make, or fail to make, with a single nucleotide, U2504 (Escherichia coli). In the ribosome, the position of U2504 is controlled by its interactions with neighboring nucleotides, whose identities vary among kingdoms.
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==About this Structure==
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U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.,Gurel G, Blaha G, Moore PB, Steitz TA J Mol Biol. 2009 May 29;389(1):146-56. Epub 2009 Apr 9. PMID:19362093<ref>PMID:19362093</ref>
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[[3g6e]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G6E OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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</div>
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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== References ==
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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<references/>
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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__TOC__
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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</StructureSection>
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L34|Ribosomal protein L34]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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==Reference==
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<ref group="xtra">PMID:019362093</ref><references group="xtra"/>
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Blaha, G.]]
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[[Category: Blaha, G]]
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[[Category: Gurel, G.]]
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[[Category: Gurel, G]]
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[[Category: Moore, P B.]]
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[[Category: Moore, P B]]
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[[Category: Steitz, T A.]]
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[[Category: Steitz, T A]]
[[Category: Antibiotic specificity]]
[[Category: Antibiotic specificity]]
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[[Category: Haloarcula marismortui]]
 
[[Category: Homoharringtonine]]
[[Category: Homoharringtonine]]
[[Category: Large ribosomal subunit]]
[[Category: Large ribosomal subunit]]

Revision as of 13:54, 17 December 2014

Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit

3g6e, resolution 2.70Å

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