1p58

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[[Image:1p58.gif|left|200px]]<br /><applet load="1p58" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1p58.gif|left|200px]]
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caption="1p58" />
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'''Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction'''<br />
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{{Structure
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|PDB= 1p58 |SIZE=350|CAPTION= <scene name='initialview01'>1p58</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1P58 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P58 OCA].
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1P58 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_type_3 Dengue virus type 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P58 OCA].
==Reference==
==Reference==
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Visualization of membrane protein domains by cryo-electron microscopy of dengue virus., Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ, Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14528291 14528291]
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Visualization of membrane protein domains by cryo-electron microscopy of dengue virus., Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ, Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14528291 14528291]
[[Category: Dengue virus type 3]]
[[Category: Dengue virus type 3]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: membrane protein m]]
[[Category: membrane protein m]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:19:58 2008''

Revision as of 11:19, 20 March 2008

Image:1p58.gif


PDB ID 1p58

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Coordinates: save as pdb, mmCIF, xml



Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction


Overview

Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses. The structure of mature dengue virus particles was determined to a resolution of 9.5 A by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. The alpha-helical 'stem' regions of the E molecules, as well as part of the N-terminal section of the M proteins, are buried in the outer leaflet of the viral membrane. The 'anchor' regions of E and the M proteins each form antiparallel E-E and M-M transmembrane alpha-helices, leaving their C termini on the exterior of the viral membrane, consistent with the predicted topology of the unprocessed polyprotein. This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus.

About this Structure

1P58 is a Protein complex structure of sequences from Dengue virus type 3. Full crystallographic information is available from OCA.

Reference

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus., Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ, Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:14528291

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