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1p53

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[[Image:1p53.gif|left|200px]]<br /><applet load="1p53" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1p53.gif|left|200px]]
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caption="1p53, resolution 3.06&Aring;" />
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'''The Crystal Structure of ICAM-1 D3-D5 fragment'''<br />
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{{Structure
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|PDB= 1p53 |SIZE=350|CAPTION= <scene name='initialview01'>1p53</scene>, resolution 3.06&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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|ACTIVITY=
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|GENE= ICAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''The Crystal Structure of ICAM-1 D3-D5 fragment'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1P53 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=NDG:'>NDG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P53 OCA].
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1P53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P53 OCA].
==Reference==
==Reference==
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Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15099525 15099525]
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Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15099525 15099525]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: igsf domain]]
[[Category: igsf domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:00 2008''

Revision as of 11:20, 20 March 2008

Image:1p53.gif


PDB ID 1p53

Drag the structure with the mouse to rotate
, resolution 3.06Å
Ligands: and
Gene: ICAM1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



The Crystal Structure of ICAM-1 D3-D5 fragment


Contents

Overview

We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling.

Disease

Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]

About this Structure

1P53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:15099525

Page seeded by OCA on Thu Mar 20 13:20:00 2008

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