1p57

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[[Image:1p57.jpg|left|200px]]<br /><applet load="1p57" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1p57.jpg|left|200px]]
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caption="1p57, resolution 1.75&Aring;" />
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'''Extracellular domain of human hepsin'''<br />
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{{Structure
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|PDB= 1p57 |SIZE=350|CAPTION= <scene name='initialview01'>1p57</scene>, resolution 1.75&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CR4:2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE'>CR4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Extracellular domain of human hepsin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1P57 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CR4:'>CR4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P57 OCA].
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1P57 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P57 OCA].
==Reference==
==Reference==
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The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain., Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA, Structure. 2003 Sep;11(9):1123-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12962630 12962630]
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The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain., Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA, Structure. 2003 Sep;11(9):1123-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12962630 12962630]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: srcr]]
[[Category: srcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:01 2008''

Revision as of 11:20, 20 March 2008

Image:1p57.jpg


PDB ID 1p57

Drag the structure with the mouse to rotate
, resolution 1.75Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Extracellular domain of human hepsin


Overview

Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.

About this Structure

1P57 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain., Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA, Structure. 2003 Sep;11(9):1123-31. PMID:12962630

Page seeded by OCA on Thu Mar 20 13:20:01 2008

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