2kqt

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{{STRUCTURE_2kqt| PDB=2kqt | SCENE= }}
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==Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine==
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===Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine===
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<StructureSection load='2kqt' size='340' side='right' caption='[[2kqt]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_17384070}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kqt]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KQT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=308:(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DECAN-1-AMINE'>308</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kad|2kad]], [[2h95|2h95]], [[2rlf|2rlf]], [[3c9j|3c9j]], [[1nyj|1nyj]], [[3bkd|3bkd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kqt RCSB], [http://www.ebi.ac.uk/pdbsum/2kqt PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we present a structure of the M2 trans-membrane domain blocked with amantadine, built using orientational constraints obtained from solid-state NMR polarization-inversion-spin-exchange-at-the-magic-angle experiments. The data indicates a kink in the monomer between two helical fragments having 20 degrees and 31 degrees tilt angles with respect to the membrane normal. This monomer structure is then used to construct a plausible model of the tetrameric amantadine-blocked M2 trans-membrane channel. The influence of amantadine binding through comparative cross polarization magic-angle spinning spectra was also observed. In addition, spectra are shown of the amantadine-resistant mutant, S31N, in the presence and absence of amantadine.
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==About this Structure==
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Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus.,Hu J, Asbury T, Achuthan S, Li C, Bertram R, Quine JR, Fu R, Cross TA Biophys J. 2007 Jun 15;92(12):4335-43. Epub 2007 Mar 23. PMID:17384070<ref>PMID:17384070</ref>
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[[2kqt]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQT OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
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*[[M2 protein|M2 protein]]
*[[M2 protein|M2 protein]]
*[[Molecular Playground/Influenza A M2 transmembrane domain|Molecular Playground/Influenza A M2 transmembrane domain]]
*[[Molecular Playground/Influenza A M2 transmembrane domain|Molecular Playground/Influenza A M2 transmembrane domain]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017384070</ref><ref group="xtra">PMID:020130653</ref><references group="xtra"/>
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__TOC__
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[[Category: Cady, S D.]]
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</StructureSection>
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[[Category: DeGrado, W F.]]
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[[Category: Cady, S D]]
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[[Category: Hong, M.]]
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[[Category: DeGrado, W F]]
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[[Category: Schmidt-Rohr, K.]]
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[[Category: Hong, M]]
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[[Category: Soto, C S.]]
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[[Category: Schmidt-Rohr, K]]
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[[Category: Wang, J.]]
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[[Category: Soto, C S]]
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[[Category: Wang, J]]
[[Category: Amantadine]]
[[Category: Amantadine]]
[[Category: Influenza]]
[[Category: Influenza]]

Revision as of 14:03, 17 December 2014

Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine

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