1p5w
From Proteopedia
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| - | [[Image:1p5w.gif|left|200px]] | + | [[Image:1p5w.gif|left|200px]] |
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| - | '''The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants''' | + | {{Structure |
| + | |PDB= 1p5w |SIZE=350|CAPTION= <scene name='initialview01'>1p5w</scene>, resolution 3.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P5W is a [ | + | 1P5W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canine_parvovirus Canine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5W OCA]. |
==Reference== | ==Reference== | ||
| - | Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants., Govindasamy L, Hueffer K, Parrish CR, Agbandje-McKenna M, J Virol. 2003 Nov;77(22):12211-21. PMID:[http:// | + | Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants., Govindasamy L, Hueffer K, Parrish CR, Agbandje-McKenna M, J Virol. 2003 Nov;77(22):12211-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14581558 14581558] |
[[Category: Canine parvovirus]] | [[Category: Canine parvovirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: parvovirade]] | [[Category: parvovirade]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:16 2008'' |
Revision as of 11:20, 20 March 2008
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| , resolution 3.3Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
The structures of host range controlling regions of the capsids of canine and feline parvoviruses and mutants
Overview
Canine parvovirus (CPV) and feline panleukopenia virus (FPV) differ in their ability to infect dogs and dog cells. Canine cell infection is a specific property of CPV and depends on the ability of the virus to bind the canine transferrin receptor (TfR), as well as other unidentified factors. Three regions in the capsid structure, located around VP2 residues 93, 300, and 323, can all influence canine TfR binding and canine cell infection. These regions were compared in the CPV and FPV capsid structures that have been determined, as well as in two new structures of CPV capsids that contain substitutions of the VP2 Asn-93 to Asp and Arg, respectively. The new structures, determined by X-ray crystallography to 3.2 and 3.3 A resolutions, respectively, clearly showed differences in the interactions of residue 93 with an adjacent loop on the capsid surface. Each of the three regions show small differences in structure, but each appears to be structurally independent of the others, and the changes likely act together to affect the ability of the capsid to bind the canine TfR and to infect canine cells. This emphasizes the complex nature of capsid alterations that change the virus-cell interaction to allow infection of cells from different hosts.
About this Structure
1P5W is a Single protein structure of sequence from Canine parvovirus. Full crystallographic information is available from OCA.
Reference
Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants., Govindasamy L, Hueffer K, Parrish CR, Agbandje-McKenna M, J Virol. 2003 Nov;77(22):12211-21. PMID:14581558
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