3d9s
From Proteopedia
(Difference between revisions)
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- | + | ==Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure== | |
- | + | <StructureSection load='3d9s' size='340' side='right' caption='[[3d9s]], [[Resolution|resolution]] 2.00Å' scene=''> | |
- | { | + | == Structural highlights == |
+ | <table><tr><td colspan='2'>[[3d9s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D9S FirstGlance]. <br> | ||
+ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PS6:O-[(S)-{[(2S)-2-(HEXANOYLOXY)-3-(TETRADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-D-SERINE'>PS6</scene></td></tr> | ||
+ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AQP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d9s RCSB], [http://www.ebi.ac.uk/pdbsum/3d9s PDBsum]</span></td></tr> | ||
+ | </table> | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d9/3d9s_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Human aquaporin 5 (HsAQP5) facilitates the transport of water across plasma membranes and has been identified within cells of the stomach, duodenum, pancreas, airways, lungs, salivary glands, sweat glands, eyes, lacrimal glands, and the inner ear. AQP5, like AQP2, is subject to posttranslational regulation by phosphorylation, at which point it is trafficked between intracellular storage compartments and the plasma membrane. Details concerning the molecular mechanism of membrane trafficking are unknown. Here we report the x-ray structure of HsAQP5 to 2.0-A resolution and highlight structural similarities and differences relative to other eukaryotic aquaporins. A lipid occludes the putative central pore, preventing the passage of gas or ions through the center of the tetramer. Multiple consensus phosphorylation sites are observed in the structure and their potential regulatory role is discussed. We postulate that a change in the conformation of the C terminus may arise from the phosphorylation of AQP5 and thereby signal trafficking. | ||
- | + | High-resolution x-ray structure of human aquaporin 5.,Horsefield R, Norden K, Fellert M, Backmark A, Tornroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U, Neutze R Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13327-32. Epub 2008 Sep 3. PMID:18768791<ref>PMID:18768791</ref> | |
- | + | ||
+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
==See Also== | ==See Also== | ||
*[[Aquaporin|Aquaporin]] | *[[Aquaporin|Aquaporin]] | ||
- | + | == References == | |
- | == | + | <references/> |
- | < | + | __TOC__ |
+ | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: Backmark, A | + | [[Category: Backmark, A]] |
- | [[Category: Fellert, M | + | [[Category: Fellert, M]] |
- | [[Category: Horsefield, R | + | [[Category: Horsefield, R]] |
- | [[Category: Johanson, U | + | [[Category: Johanson, U]] |
- | [[Category: Kjellbom, P | + | [[Category: Kjellbom, P]] |
- | [[Category: Kvassman, J | + | [[Category: Kvassman, J]] |
- | [[Category: Neutze, R | + | [[Category: Neutze, R]] |
- | [[Category: Norden, K | + | [[Category: Norden, K]] |
- | [[Category: Scheltinga, A C.Terwisscha Van | + | [[Category: Scheltinga, A C.Terwisscha Van]] |
- | [[Category: Tornroth-Horsefield, S | + | [[Category: Tornroth-Horsefield, S]] |
[[Category: Aqp]] | [[Category: Aqp]] | ||
[[Category: Aquaglyceroporin]] | [[Category: Aquaglyceroporin]] |
Revision as of 14:08, 17 December 2014
Human Aquaporin 5 (AQP5) - High Resolution X-ray Structure
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Categories: Homo sapiens | Backmark, A | Fellert, M | Horsefield, R | Johanson, U | Kjellbom, P | Kvassman, J | Neutze, R | Norden, K | Scheltinga, A C.Terwisscha Van | Tornroth-Horsefield, S | Aqp | Aquaglyceroporin | Aquaporin | Ar/r | Glycoprotein | Lipid | Membrane | Membrane protein | Npa | Phosphatidylserine | Psf | Transmembrane | Transport | Water channel | Water transport