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1j6z
From Proteopedia
(Difference between revisions)
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| - | + | ==UNCOMPLEXED ACTIN== | |
| - | === | + | <StructureSection load='1j6z' size='340' side='right' caption='[[1j6z]], [[Resolution|resolution]] 1.54Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1j6z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J6Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=RHO:TETRAMETHYLRHODAMINE-5-MALEIMIDE'>RHO</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1atn|1atn]], [[2btf|2btf]], [[1db0|1db0]], [[1dga|1dga]], [[1eqy|1eqy]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j6z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j6z RCSB], [http://www.ebi.ac.uk/pdbsum/1j6z PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The dynamics and polarity of actin filaments are controlled by a conformational change coupled to the hydrolysis of adenosine 5'-triphosphate (ATP) by a mechanism that remains to be elucidated. Actin modified to block polymerization was crystallized in the adenosine 5'-diphosphate (ADP) state, and the structure was solved to 1.54 angstrom resolution. Compared with previous ATP-actin structures from complexes with deoxyribonuclease I, profilin, and gelsolin, monomeric ADP-actin is characterized by a marked conformational change in subdomain 2. The successful crystallization of monomeric actin opens the way to future structure determinations of actin complexes with actin-binding proteins such as myosin. | ||
| - | + | The crystal structure of uncomplexed actin in the ADP state.,Otterbein LR, Graceffa P, Dominguez R Science. 2001 Jul 27;293(5530):708-11. PMID:11474115<ref>PMID:11474115</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Actin|Actin]] | *[[Actin|Actin]] | ||
*[[Non-polymerizable monomeric actin|Non-polymerizable monomeric actin]] | *[[Non-polymerizable monomeric actin|Non-polymerizable monomeric actin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
| - | [[Category: Dominguez, R | + | [[Category: Dominguez, R]] |
| - | [[Category: Graceffa, P | + | [[Category: Graceffa, P]] |
| - | [[Category: Otterbein, L R | + | [[Category: Otterbein, L R]] |
[[Category: Actin]] | [[Category: Actin]] | ||
[[Category: Adp-state]] | [[Category: Adp-state]] | ||
[[Category: Contractile protein]] | [[Category: Contractile protein]] | ||
[[Category: Tetramethylrhodamine-5-maleimide]] | [[Category: Tetramethylrhodamine-5-maleimide]] | ||
Revision as of 14:09, 17 December 2014
UNCOMPLEXED ACTIN
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