3fus

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{{STRUCTURE_3fus| PDB=3fus | SCENE= }}
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==Improved Structure of the Unliganded Simian Immunodeficiency Virus gp120 Core==
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===Improved Structure of the Unliganded Simian Immunodeficiency Virus gp120 Core===
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<StructureSection load='3fus' size='340' side='right' caption='[[3fus]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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{{ABSTRACT_PUBMED_15698564}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3fus]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FUS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bf1|2bf1]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11723 Simian immunodeficiency virus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fus RCSB], [http://www.ebi.ac.uk/pdbsum/3fus PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/3fus_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HIV/SIV envelope glycoproteins mediate the first steps in viral infection. They are trimers of a membrane-anchored polypeptide chain, cleaved into two fragments known as gp120 and gp41. The structure of HIV gp120 bound with receptor (CD4) has been known for some time. We have now determined the structure of a fully glycosylated SIV gp120 envelope glycoprotein in an unliganded conformation by X-ray crystallography at 4.0 A resolution. We describe here our experimental and computational approaches, which may be relevant to other resolution-limited crystallographic problems. Key issues were attention to details of beam geometry mandated by small, weakly diffracting crystals, and choice of strategies for phase improvement, starting with two isomorphous derivatives and including multicrystal averaging. We validated the structure by analyzing composite omit maps, averaged among three distinct crystal lattices, and by calculating model-based, SeMet anomalous difference maps. There are at least four ordered sugars on many of the thirteen oligosaccharides.
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==About this Structure==
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Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.,Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SC Structure. 2005 Feb;13(2):197-211. PMID:15698564<ref>PMID:15698564</ref>
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[[3fus]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUS OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Gp120|Gp120]]
*[[Gp120|Gp120]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015698564</ref><ref group="xtra">PMID:019307715</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Simian immunodeficiency virus]]
[[Category: Simian immunodeficiency virus]]
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[[Category: Chen, X.]]
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[[Category: Chen, X]]
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[[Category: Ma, J.]]
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[[Category: Ma, J]]
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[[Category: Poon, B.]]
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[[Category: Poon, B]]
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[[Category: Wang, Q.]]
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[[Category: Wang, Q]]
[[Category: Aid]]
[[Category: Aid]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]

Revision as of 14:11, 17 December 2014

Improved Structure of the Unliganded Simian Immunodeficiency Virus gp120 Core

3fus, resolution 4.00Å

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