3cxc

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{{Large structure}}
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==The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui==
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{{STRUCTURE_3cxc| PDB=3cxc | SCENE= }}
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<StructureSection load='3cxc' size='340' side='right' caption='[[3cxc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_18947996}}
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<table><tr><td colspan='2'>[[3cxc]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3CXC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SLD:(3Z)-N-[(4E)-5-(4-{(5S)-5-[(ACETYLAMINO)METHYL]-2-OXO-1,3-OXAZOLIDIN-3-YL}-2-FLUOROPHENYL)PENT-4-EN-1-YL]-3-(4-METHYL-2,6-DIOXO-1,6-DIHYDROPYRIMIDIN-5(2H)-YLIDENE)PROPANAMIDE'>SLD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cxc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3cxc RCSB], [http://www.ebi.ac.uk/pdbsum/3cxc PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cx/3cxc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.
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==About this Structure==
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Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.,Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, Johnson G Bioorg Med Chem Lett. 2008 Dec 1;18(23):6175-8. Epub 2008 Oct 7. PMID:18947996<ref>PMID:18947996</ref>
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[[3cxc]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CXC OCA].
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==See Also==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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*[[Ribosomal protein L10|Ribosomal protein L10]]
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</div>
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*[[Ribosomal protein L13|Ribosomal protein L13]]
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*[[Ribosomal protein L14|Ribosomal protein L14]]
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*[[Ribosomal protein L15|Ribosomal protein L15]]
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*[[Ribosomal protein L18|Ribosomal protein L18]]
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*[[Ribosomal protein L19|Ribosomal protein L19]]
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*[[Ribosomal protein L2|Ribosomal protein L2]]
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*[[Ribosomal protein L21|Ribosomal protein L21]]
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*[[Ribosomal protein L22|Ribosomal protein L22]]
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*[[Ribosomal protein L23|Ribosomal protein L23]]
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*[[Ribosomal protein L24|Ribosomal protein L24]]
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*[[Ribosomal protein L25|Ribosomal protein L25]]
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*[[Ribosomal protein L29|Ribosomal protein L29]]
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*[[Ribosomal protein L3|Ribosomal protein L3]]
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*[[Ribosomal protein L30|Ribosomal protein L30]]
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*[[Ribosomal protein L4|Ribosomal protein L4]]
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*[[Ribosomal protein L5|Ribosomal protein L5]]
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*[[Ribosomal protein L6|Ribosomal protein L6]]
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*[[Ribosomal protein L7|Ribosomal protein L7]]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:018947996</ref><references group="xtra"/>
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Duffy, E M.]]
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[[Category: Duffy, E M]]
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[[Category: Ippolito, J A.]]
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[[Category: Ippolito, J A]]
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[[Category: Kanyo, Z F.]]
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[[Category: Kanyo, Z F]]
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[[Category: Wang, D.]]
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[[Category: Wang, D]]
[[Category: 50s ribosomal subunit]]
[[Category: 50s ribosomal subunit]]
[[Category: Oxazolidinone]]
[[Category: Oxazolidinone]]
[[Category: Ribosome]]
[[Category: Ribosome]]

Revision as of 14:13, 17 December 2014

The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui

3cxc, resolution 3.00Å

Drag the structure with the mouse to rotate

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OCA

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