1p79
From Proteopedia
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| - | [[Image:1p79.gif|left|200px]] | + | [[Image:1p79.gif|left|200px]] |
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| - | '''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex''' | + | {{Structure |
| + | |PDB= 1p79 |SIZE=350|CAPTION= <scene name='initialview01'>1p79</scene>, resolution 1.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P79 is a [ | + | 1P79 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P79 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:[http:// | + | Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14604532 14604532] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pan, B.]] | [[Category: Pan, B.]] | ||
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[[Category: tetraplex]] | [[Category: tetraplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:20:52 2008'' |
Revision as of 11:20, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a bulged RNA tetraplex: implications for a novel binding site in RNA tetraplex
Overview
Bulges are an important structural motif in RNA and can be used as recognition and interaction sites in RNA-protein interaction and RNA-RNA interaction. Here we report the first crystal structure of a bulged RNA tetraplex at 1.1 A resolution. The hexamer r(U)(BrdG)r(UGGU) forms a parallel tetraplex with the uridine sandwiched by guanines bulging out. The bulged uridine adopts the syn glycosidic conformation and its O2 and N3 atoms face outwards, serving as an effective recognition and interaction site. The bulge formation both widens the groove width and changes the groove hydrogen-bonding pattern on its 5' side. However, the bulge does not make any bends or kinks in the tetraplex structure. The present study demonstrates the dramatic difference between uridine and guanine in forming tetraplex structure. In addition, both G(syn) tetrad and G(anti) tetrad have been observed. They display the same base-pairing pattern and similar C1'-C1' distance but different hydrogen-bonding patterns in the groove.
About this Structure
1P79 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a bulged RNA tetraplex at 1.1 a resolution: implications for a novel binding site in RNA tetraplex., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Nov;11(11):1423-30. PMID:14604532
Page seeded by OCA on Thu Mar 20 13:20:52 2008
Categories: Protein complex | Pan, B. | Shi, K. | Sundaralingam, M. | Xiong, Y. | K | Bulge | Rna | Tetraplex
