3ijc

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{{STRUCTURE_3ijc| PDB=3ijc | SCENE= }}
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==Crystal structure of Eed in complex with NDSB-195==
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===Crystal structure of Eed in complex with NDSB-195===
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<StructureSection load='3ijc' size='340' side='right' caption='[[3ijc]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19767730}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ijc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IJC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDS:ETHYL+DIMETHYL+AMMONIO+PROPANE+SULFONATE'>NDS</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qxv|2qxv]], [[3iiw|3iiw]], [[3iiy|3iiy]], [[3ij0|3ij0]], [[3ij1|3ij1]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ijc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ijc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ijc RCSB], [http://www.ebi.ac.uk/pdbsum/3ijc PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ij/3ijc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells.
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==About this Structure==
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Role of the polycomb protein EED in the propagation of repressive histone marks.,Margueron R, Justin N, Ohno K, Sharpe ML, Son J, Drury WJ 3rd, Voigt P, Martin SR, Taylor WR, De Marco V, Pirrotta V, Reinberg D, Gamblin SJ Nature. 2009 Oct 8;461(7265):762-7. Epub 2009 Sep 20. PMID:19767730<ref>PMID:19767730</ref>
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[[3ijc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IJC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019767730</ref><references group="xtra"/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gamblin, S J.]]
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[[Category: Gamblin, S J]]
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[[Category: Justin, N.]]
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[[Category: Justin, N]]
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[[Category: Marco, V De.]]
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[[Category: Marco, V De]]
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[[Category: Martin, S.]]
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[[Category: Martin, S]]
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[[Category: Sharpe, M L.]]
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[[Category: Sharpe, M L]]
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[[Category: Taylor, W R.]]
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[[Category: Taylor, W R]]
[[Category: Alternative initiation]]
[[Category: Alternative initiation]]
[[Category: Chromatin regulator]]
[[Category: Chromatin regulator]]

Revision as of 05:59, 18 December 2014

Crystal structure of Eed in complex with NDSB-195

3ijc, resolution 1.95Å

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