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3iec

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{{STRUCTURE_3iec| PDB=3iec | SCENE= }}
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==Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates==
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===Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates===
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<StructureSection load='3iec' size='340' side='right' caption='[[3iec]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19966800}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3iec]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IEC FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CagA, EMK1, MARK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), cagA, cai ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iec RCSB], [http://www.ebi.ac.uk/pdbsum/3iec PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3iec_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The CagA protein of Helicobacter pylori interacts with numerous cellular factors and is associated with increased virulence and risk of gastric carcinoma. We present here the cocrystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrates of this kinase family, resembling eukaryotic protein kinase inhibitors. Mutagenesis of conserved residues central to this interaction renders CagA inactive as an inhibitor of MARK2.
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==About this Structure==
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Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates.,Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE Nat Struct Mol Biol. 2010 Jan;17(1):130-2. Epub 2009 Dec 6. PMID:19966800<ref>PMID:19966800</ref>
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[[3iec]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IEC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:019966800</ref><references group="xtra"/>
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</div>
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==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Miller, M.]]
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[[Category: Miller, M]]
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[[Category: Nesic, D.]]
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[[Category: Nesic, D]]
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[[Category: Stebbins, C E.]]
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[[Category: Stebbins, C E]]
[[Category: Alternative promoter usage]]
[[Category: Alternative promoter usage]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]

Revision as of 06:06, 18 December 2014

Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

3iec, resolution 2.20Å

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