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1p9x
From Proteopedia
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| - | [[Image:1p9x.gif|left|200px]] | + | [[Image:1p9x.gif|left|200px]] |
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| - | '''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC''' | + | {{Structure |
| + | |PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1P9X is a [ | + | 1P9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA]. |
==Reference== | ==Reference== | ||
| - | Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:[http:// | + | Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837804 12837804] |
[[Category: Deinococcus radiodurans]] | [[Category: Deinococcus radiodurans]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ketolide]] | [[Category: ketolide]] | ||
[[Category: macrolide]] | [[Category: macrolide]] | ||
| - | [[Category: | + | [[Category: ribosome]] |
[[Category: trna]] | [[Category: trna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:49 2008'' |
Revision as of 11:21, 20 March 2008
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| , resolution 3.40Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC
Overview
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
About this Structure
1P9X is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.
Reference
Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804
Page seeded by OCA on Thu Mar 20 13:21:49 2008
Categories: Deinococcus radiodurans | Single protein | Berisio, R. | Fucini, P. | Hansen, H A. | Harms, J. | Schluenzen, F. | Yonath, A. | Zarivach, R. | TEL | Antibiotic | Blockage | Exit-tunnel | Ketolide | Macrolide | Ribosome | Trna
