3kic

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{{Large structure}}
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==Crystal structure of adeno-associated virus serotype 3B==
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{{STRUCTURE_3kic| PDB=3kic | SCENE= }}
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<StructureSection load='3kic' size='340' side='right' caption='[[3kic]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===Crystal structure of adeno-associated virus serotype 3B===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_20444480}}
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<table><tr><td colspan='2'>[[3kic]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KIC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D5M:2-DEOXYADENOSINE-5-MONOPHOSPHATE'>D5M</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kie|3kie]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10239 Viruses])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kic RCSB], [http://www.ebi.ac.uk/pdbsum/3kic PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ki/3kic_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Adeno-associated viruses (AAVs) are leading candidate vectors for human gene therapy. AAV serotypes have broad cellular tropism and use a variety of cellular receptors. AAV serotype 3 binds to heparan sulfate proteoglycan prior to cell entry and is serologically distinct from other serotypes. The capsid features that distinguish AAV-3B from other serotypes are poorly understood. The structure of AAV-3B has been determined to 2.6A resolution from twinned crystals of an infectious virus. The most distinctive structural features are located in regions implicated in receptor and antibody binding, providing insights into the cell entry mechanisms and antigenic nature of AAVs. We show that AAV-3B has a lower affinity for heparin than AAV-2, which can be rationalized by the distinct features of the AAV-3B capsid. The structure of AAV-3B provides an additional foundation for the future engineering of improved gene therapy vectors with modified receptor binding or antigenic characteristics.
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==About this Structure==
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The structure of adeno-associated virus serotype 3B (AAV-3B): insights into receptor binding and immune evasion.,Lerch TF, Xie Q, Chapman MS Virology. 2010 Jul 20;403(1):26-36. Epub 2010 May 4. PMID:20444480<ref>PMID:20444480</ref>
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[[3kic]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KIC OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Virus coat protein|Virus coat protein]]
*[[Virus coat protein|Virus coat protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020444480</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Viruses]]
[[Category: Viruses]]
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[[Category: Chapman, M S.]]
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[[Category: Chapman, M S]]
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[[Category: Lerch, T F.]]
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[[Category: Lerch, T F]]
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[[Category: Xie, Q.]]
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[[Category: Xie, Q]]
[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Capsid]]
[[Category: Capsid]]

Revision as of 06:19, 18 December 2014

Crystal structure of adeno-associated virus serotype 3B

3kic, resolution 2.60Å

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