3iyn

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{{Large structure}}
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==3.6-Angstrom cryoEM structure of human adenovirus type 5==
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{{STRUCTURE_3iyn| PDB=3iyn | SCENE= }}
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<StructureSection load='3iyn' size='340' side='right' caption='[[3iyn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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===3.6-Angstrom cryoEM structure of human adenovirus type 5===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_20798312}}
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<table><tr><td colspan='2'>[[3iyn]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IYN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iyn RCSB], [http://www.ebi.ac.uk/pdbsum/3iyn PDBsum]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/3iyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Construction of a complex virus may involve a hierarchy of assembly elements. Here, we report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo-electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins (IIIa, VIII, and IX), extensions of the (penton base and hexon) major capsid proteins, and interactions within three protein-protein networks. One network is mediated by protein IIIa at the vertices, within group-of-six (GOS) tiles--a penton base and its five surrounding hexons. Another is mediated by ropes (protein IX) that lash hexons together to form group-of-nine (GON) tiles and bind GONs to GONs. The third, mediated by IIIa and VIII, binds each GOS to five surrounding GONs. Optimization of adenovirus for cancer and gene therapy could target these networks.
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==About this Structure==
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Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks.,Liu H, Jin L, Koh SB, Atanasov I, Schein S, Wu L, Zhou ZH Science. 2010 Aug 27;329(5995):1038-43. PMID:20798312<ref>PMID:20798312</ref>
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[[3iyn]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYN OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:020798312</ref><references group="xtra"/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Adenovirus]]
[[Category: Adenovirus]]
[[Category: Human adenovirus 5]]
[[Category: Human adenovirus 5]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Atanasov, I.]]
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[[Category: Atanasov, I]]
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[[Category: Jin, L.]]
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[[Category: Jin, L]]
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[[Category: Koh, S B.S.]]
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[[Category: Koh, S B.S]]
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[[Category: Liu, H.]]
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[[Category: Liu, H]]
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[[Category: Schein, S.]]
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[[Category: Schein, S]]
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[[Category: Wu, L.]]
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[[Category: Wu, L]]
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[[Category: Zhou, Z H.]]
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[[Category: Zhou, Z H]]
[[Category: 3d reconstruction]]
[[Category: 3d reconstruction]]
[[Category: Capsid protein]]
[[Category: Capsid protein]]

Revision as of 06:24, 18 December 2014

3.6-Angstrom cryoEM structure of human adenovirus type 5

3iyn, resolution 3.60Å

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