3p30

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{{STRUCTURE_3p30| PDB=3p30 | SCENE= }}
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==crystal structure of the cluster II Fab 1281 in complex with HIV-1 gp41 ectodomain==
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===crystal structure of the cluster II Fab 1281 in complex with HIV-1 gp41 ectodomain===
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<StructureSection load='3p30' size='340' side='right' caption='[[3p30]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21076402}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p30]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P30 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P30 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HIV-1 ENV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p30 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p30 RCSB], [http://www.ebi.ac.uk/pdbsum/3p30 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HIV-1 envelope glycoprotein gp41 undergoes large conformational changes to drive fusion of viral and target cell membranes, adopting at least three distinct conformations during the viral entry process. Neutralizing antibodies against gp41 block HIV-1 infection by targeting gp41's membrane-proximal external region in a fusion-intermediate state. Here we report biochemical and structural evidence that non-neutralizing antibodies, capable of binding with high affinity to an immunodominant segment adjacent to the neutralizing epitopes in the membrane-proximal region, recognize a gp41 conformation that exists only when membrane fusion is complete. We propose that these non-neutralizing antibodies are induced in HIV-1-infected individuals by gp41 in a triggered, postfusion form and contribute to production of ineffective humoral responses. These results have important implications for gp41-based vaccine design.
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==About this Structure==
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Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.,Frey G, Chen J, Rits-Volloch S, Freeman MM, Zolla-Pazner S, Chen B Nat Struct Mol Biol. 2010 Dec;17(12):1486-91. Epub 2010 Nov 14. PMID:21076402<ref>PMID:21076402</ref>
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[[3p30]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P30 OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Hiv env proteins|Hiv env proteins]]
*[[Hiv env proteins|Hiv env proteins]]
*[[Monoclonal Antibody|Monoclonal Antibody]]
*[[Monoclonal Antibody|Monoclonal Antibody]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:021076402</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Chen, B.]]
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[[Category: Chen, B]]
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[[Category: Chen, J.]]
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[[Category: Chen, J]]
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[[Category: Freeman, M M.]]
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[[Category: Freeman, M M]]
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[[Category: Frey, G.]]
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[[Category: Frey, G]]
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[[Category: Rits-Volloch, S.]]
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[[Category: Rits-Volloch, S]]
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[[Category: Zolla-Pazner, S.]]
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[[Category: Zolla-Pazner, S]]
[[Category: 6-helix bundle]]
[[Category: 6-helix bundle]]
[[Category: Cluster 2]]
[[Category: Cluster 2]]

Revision as of 08:25, 18 December 2014

crystal structure of the cluster II Fab 1281 in complex with HIV-1 gp41 ectodomain

3p30, resolution 3.30Å

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