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1pe0
From Proteopedia
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| - | [[Image:1pe0.gif|left|200px]] | + | [[Image:1pe0.gif|left|200px]] |
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| - | '''Crystal structure of the K130R mutant of human DJ-1''' | + | {{Structure |
| + | |PDB= 1pe0 |SIZE=350|CAPTION= <scene name='initialview01'>1pe0</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the K130R mutant of human DJ-1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PE0 is a [ | + | 1PE0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE0 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease., Tao X, Tong L, J Biol Chem. 2003 Aug 15;278(33):31372-9. Epub 2003 May 21. PMID:[http:// | + | Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease., Tao X, Tong L, J Biol Chem. 2003 Aug 15;278(33):31372-9. Epub 2003 May 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12761214 12761214] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: dj-1]] | [[Category: dj-1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:23:11 2008'' |
Revision as of 11:23, 20 March 2008
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| , resolution 1.70Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the K130R mutant of human DJ-1
Contents |
Overview
We report the crystal structure at 1.8-A resolution of human DJ-1, which has been linked to early onset Parkinson's disease. The monomer of DJ-1 contains the alpha/beta-fold that is conserved among members of the DJ-1/ThiJ/PfpI superfamily. However, the structure also contains an extra helix at the C terminus, which mediates a novel mode of dimerization for the DJ-1 proteins. A putative active site has been identified near the dimer interface, and the residues Cys-106, His-126, and Glu-18 may play important roles in the catalysis by this protein. Studies with the disease-causing L166P mutant suggest that the mutation has disrupted the C-terminal region and the dimerization of the protein. The DJ-1 proteins may function only as dimers. The Lys to Arg mutation at residue 130, the site of sumoylation of DJ-1, has minimal impact on the structure of the protein.
Disease
Known diseases associated with this structure: Amyotrophic lateral sclerosis-Parkinsonism/dementia complex 2 OMIM:[602533], Parkinson disease 7, autosomal recessive early-onset OMIM:[602533]
About this Structure
1PE0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease., Tao X, Tong L, J Biol Chem. 2003 Aug 15;278(33):31372-9. Epub 2003 May 21. PMID:12761214
Page seeded by OCA on Thu Mar 20 13:23:11 2008
Categories: Homo sapiens | Single protein | Tao, X. | Tong, L. | Dj-1
