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3mqe
From Proteopedia
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| - | + | ==Structure of SC-75416 bound at the COX-2 active site== | |
| - | + | <StructureSection load='3mqe' size='340' side='right' caption='[[3mqe]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3mqe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MQE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=416:(2S)-7-TERT-BUTYL-6-CHLORO-2-(TRIFLUOROMETHYL)-2H-CHROMENE-3-CARBOXYLIC+ACID'>416</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pxx|1pxx]], [[3ln1|3ln1]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cox-2, Cox2, Pghs-b, Ptgs2, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mqe RCSB], [http://www.ebi.ac.uk/pdbsum/3mqe PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | In this Letter, we provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data for a series of selective COX-2 inhibitors. During the course of our structure-based drug design efforts, we discovered two distinct binding modes within the COX-2 active site for differently substituted members of this class. The challenge of a undesirably long human half-life for the first clinical candidate 1t(1/2)=360h was addressed by multiple strategies, leading to the discovery of 29b-(S) (SC-75416) with t(1/2)=34h. | ||
| - | + | The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life.,Wang JL, Limburg D, Graneto MJ, Springer J, Hamper JR, Liao S, Pawlitz JL, Kurumbail RG, Maziasz T, Talley JJ, Kiefer JR, Carter J Bioorg Med Chem Lett. 2010 Jul 24. PMID:20709553<ref>PMID:20709553</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
==See Also== | ==See Also== | ||
*[[Cyclooxygenase|Cyclooxygenase]] | *[[Cyclooxygenase|Cyclooxygenase]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Prostaglandin-endoperoxide synthase]] | [[Category: Prostaglandin-endoperoxide synthase]] | ||
| - | [[Category: Graneto, M J | + | [[Category: Graneto, M J]] |
| - | [[Category: Kiefer, J R | + | [[Category: Kiefer, J R]] |
| - | [[Category: Limburg, D | + | [[Category: Limburg, D]] |
| - | [[Category: Rogier, J | + | [[Category: Rogier, J]] |
| - | [[Category: Springer, J | + | [[Category: Springer, J]] |
| - | [[Category: Wang, J L | + | [[Category: Wang, J L]] |
[[Category: Cox-2]] | [[Category: Cox-2]] | ||
[[Category: Cox2]] | [[Category: Cox2]] | ||
Revision as of 08:30, 18 December 2014
Structure of SC-75416 bound at the COX-2 active site
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Categories: Mus musculus | Prostaglandin-endoperoxide synthase | Graneto, M J | Kiefer, J R | Limburg, D | Rogier, J | Springer, J | Wang, J L | Cox-2 | Cox2 | Cyclooxygenase-2 | Dioxygenase | Disulfide bond | Endoplasmic reticulum | Fatty acid biosynthesis | Glycoprotein | Heme | Iron | Lipid synthesis | Membrane | Metal-binding | Microsome | Oxidoreductase | Peroxidase | Pgh2s-2 | Phosphoprotein | Prostaglandin biosynthesis
