3rbl

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{{STRUCTURE_3rbl| PDB=3rbl | SCENE= }}
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==Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form==
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===Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form===
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<StructureSection load='3rbl' size='340' side='right' caption='[[3rbl]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
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{{ABSTRACT_PUBMED_22143761}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rbf|3rbf]], [[3rch|3rch]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rbl RCSB], [http://www.ebi.ac.uk/pdbsum/3rbl PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN]] Aromatic L-amino acid decarboxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN]] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DOPA decarboxylase, the dimeric enzyme responsible for the synthesis of neurotransmitters dopamine and serotonin, is involved in severe neurological diseases such as Parkinson disease, schizophrenia, and depression. Binding of the pyridoxal-5'-phosphate (PLP) cofactor to the apoenzyme is thought to represent a central mechanism for the regulation of its activity. We solved the structure of the human apoenzyme and found it exists in an unexpected open conformation: compared to the pig kidney holoenzyme, the dimer subunits move 20 A apart and the two active sites become solvent exposed. Moreover, by tuning the PLP concentration in the crystals, we obtained two more structures with different conformations of the active site. Analysis of three-dimensional data coupled to a kinetic study allows to identify the structural determinants of the open/close conformational change occurring upon PLP binding and thereby propose a model for the preferential degradation of the apoenzymes of Group II decarboxylases.
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==About this Structure==
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Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases.,Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzola F Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20514-9. Epub 2011 Dec 5. PMID:22143761<ref>PMID:22143761</ref>
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[[3rbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RBL OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[DOPA decarboxylase|DOPA decarboxylase]]
*[[DOPA decarboxylase|DOPA decarboxylase]]
*[[User:Brian Hernandez/DOPA Decarboxylase|User:Brian Hernandez/DOPA Decarboxylase]]
*[[User:Brian Hernandez/DOPA Decarboxylase|User:Brian Hernandez/DOPA Decarboxylase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022143761</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Aromatic-L-amino-acid decarboxylase]]
[[Category: Aromatic-L-amino-acid decarboxylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cellini, B.]]
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[[Category: Cellini, B]]
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[[Category: Cutruzzola, F.]]
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[[Category: Cutruzzola, F]]
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[[Category: Gianni, S.]]
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[[Category: Gianni, S]]
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[[Category: Giardina, G.]]
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[[Category: Giardina, G]]
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[[Category: Montioli, R.]]
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[[Category: Montioli, R]]
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[[Category: Paiardini, A.]]
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[[Category: Paiardini, A]]
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[[Category: Voltattorni, C Borri.]]
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[[Category: Voltattorni, C Borri]]
[[Category: Aadc deficiency]]
[[Category: Aadc deficiency]]
[[Category: Apo enzyme]]
[[Category: Apo enzyme]]

Revision as of 08:45, 18 December 2014

Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form

3rbl, resolution 3.24Å

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