1pg1
From Proteopedia
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| - | + | ==PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES== | |
| - | + | <StructureSection load='1pg1' size='340' side='right' caption='[[1pg1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[1pg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PG1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pg1 RCSB], [http://www.ebi.ac.uk/pdbsum/1pg1 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | BACKGROUND: The protegrins are a family of arginine- and cysteine-rich cationic peptides found in porcine leukocytes that exhibit a broad range of antimicrobial and antiviral activities. They are composed of 16-18 amino-acid residues including four cysteines, which form two disulfide linkages. To begin to understand the mechanism of action of these peptides, we set out to determine the structure of protegrin-1 (PG-1). RESULTS: We used two-dimensional homonuclear nuclear magnetic resonance spectroscopy to study the conformation of both natural and synthetic PG-1 under several conditions. A refined three-dimensional structure of synthetic PG-1 is presented. CONCLUSIONS: Both synthetic and natural protegrin-1 form a well-defined structure in solution composed primarily of a two-stranded antiparallel beta sheet, with strands connected by a beta turn. The structure of PG-1 suggests ways in which the peptide may interact with itself or other molecules to form the membrane pores and the large membrane-associated assemblages observed in protegrin-treated, gram-negative bacteria. | ||
| - | + | Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.,Fahrner RL, Dieckmann T, Harwig SS, Lehrer RI, Eisenberg D, Feigon J Chem Biol. 1996 Jul;3(7):543-50. PMID:8807886<ref>PMID:8807886</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
==See Also== | ==See Also== | ||
*[[Protegrin|Protegrin]] | *[[Protegrin|Protegrin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Dieckmann, T | + | [[Category: Dieckmann, T]] |
| - | [[Category: Eisenberg, D | + | [[Category: Eisenberg, D]] |
| - | [[Category: Fahrner, R L | + | [[Category: Fahrner, R L]] |
| - | [[Category: Feigon, J | + | [[Category: Feigon, J]] |
| - | [[Category: Harwig, S S.L | + | [[Category: Harwig, S S.L]] |
| - | [[Category: Lehrer, R I | + | [[Category: Lehrer, R I]] |
[[Category: Antimicrobial peptide]] | [[Category: Antimicrobial peptide]] | ||
Revision as of 11:18, 18 December 2014
PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES
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