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2lyp

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{{STRUCTURE_2lyp| PDB=2lyp | SCENE= }}
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==NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees)==
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===NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees)===
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<StructureSection load='2lyp' size='340' side='right' caption='[[2lyp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_23396077}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lyp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LYP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gzu|2gzu]], [[1utx|1utx]], [[2xi8|2xi8]], [[2xiu|2xiu]], [[2xj3|2xj3]], [[2lyj|2lyj]], [[2lyk|2lyk]], [[2lyl|2lyl]], [[2lyq|2lyq]], [[2lyr|2lyr]], [[2lys|2lys]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cylR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lyp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lyp RCSB], [http://www.ebi.ac.uk/pdbsum/2lyp PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein folding and unfolding are crucial for a range of biological phenomena and human diseases. Defining the structural properties of the involved transient species is therefore of prime interest. Using a combination of cold denaturation with NMR spectroscopy, we reveal detailed insight into the unfolding of the homodimeric repressor protein CylR2. Seven three-dimensional structures of CylR2 at temperatures from 25 degrees C to -16 degrees C reveal a progressive dissociation of the dimeric protein into a native-like monomeric intermediate followed by transition into a highly dynamic, partially folded state. The core of the partially folded state seems critical for biological function and misfolding.
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==About this Structure==
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Cold denaturation of a protein dimer monitored at atomic resolution.,Jaremko M, Jaremko L, Kim HY, Cho MK, Schwieters CD, Giller K, Becker S, Zweckstetter M Nat Chem Biol. 2013 Feb 10. doi: 10.1038/nchembio.1181. PMID:23396077<ref>PMID:23396077</ref>
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[[2lyp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LYP OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Becker, S.]]
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[[Category: Becker, S]]
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[[Category: Cho, M.]]
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[[Category: Cho, M]]
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[[Category: Giller, K.]]
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[[Category: Giller, K]]
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[[Category: Jaremko, L.]]
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[[Category: Jaremko, L]]
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[[Category: Jaremko, M.]]
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[[Category: Jaremko, M]]
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[[Category: Kim, H.]]
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[[Category: Kim, H]]
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[[Category: Schwieters, C D.]]
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[[Category: Schwieters, C D]]
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[[Category: Zweckstetter, M.]]
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[[Category: Zweckstetter, M]]
[[Category: Cold denaturation]]
[[Category: Cold denaturation]]
[[Category: Cylr2]]
[[Category: Cylr2]]

Revision as of 11:19, 18 December 2014

NOE-based 3D structure of the monomer of CylR2 in equilibrium with predissociated homodimer at 266K (-7 Celsius degrees)

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