1pk6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pk6.jpg|left|200px]]<br /><applet load="1pk6" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1pk6.jpg|left|200px]]
-
caption="1pk6, resolution 1.85&Aring;" />
+
 
-
'''Globular Head of the Complement System Protein C1q'''<br />
+
{{Structure
 +
|PDB= 1pk6 |SIZE=350|CAPTION= <scene name='initialview01'>1pk6</scene>, resolution 1.85&Aring;
 +
|SITE=
 +
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''Globular Head of the Complement System Protein C1q'''
 +
 
==Overview==
==Overview==
Line 10: Line 19:
==About this Structure==
==About this Structure==
-
1PK6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK6 OCA].
+
1PK6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PK6 OCA].
==Reference==
==Reference==
-
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties., Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ, J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12960167 12960167]
+
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties., Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ, J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12960167 12960167]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
Line 32: Line 41:
[[Category: jellyroll]]
[[Category: jellyroll]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:29:40 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:25:28 2008''

Revision as of 11:25, 20 March 2008

Image:1pk6.jpg


PDB ID 1pk6

Drag the structure with the mouse to rotate
, resolution 1.85Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Globular Head of the Complement System Protein C1q


Contents

Overview

C1q is a versatile recognition protein that binds to an amazing variety of immune and non-immune ligands and triggers activation of the classical pathway of complement. The crystal structure of the C1q globular domain responsible for its recognition properties has now been solved and refined to 1.9 A of resolution. The structure reveals a compact, almost spherical heterotrimeric assembly held together mainly by non-polar interactions, with a Ca2+ ion bound at the top. The heterotrimeric assembly of the C1q globular domain appears to be a key factor of the versatile recognition properties of this protein. Plausible three-dimensional models of the C1q globular domain in complex with two of its physiological ligands, C-reactive protein and IgG, are proposed, highlighting two of the possible recognition modes of C1q. The C1q/human IgG1 model suggests a critical role for the hinge region of IgG and for the relative orientation of its Fab domain in C1q binding.

Disease

Known diseases associated with this structure: C1q deficiency, type A OMIM:[120550], C1q deficiency, type B OMIM:[120570], C1q deficiency, type C OMIM:[120575]

About this Structure

1PK6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties., Gaboriaud C, Juanhuix J, Gruez A, Lacroix M, Darnault C, Pignol D, Verger D, Fontecilla-Camps JC, Arlaud GJ, J Biol Chem. 2003 Nov 21;278(47):46974-82. Epub 2003 Sep 5. PMID:12960167

Page seeded by OCA on Thu Mar 20 13:25:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pk6"
Personal tools