1pmi
From Proteopedia
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| - | [[Image:1pmi.gif|left|200px]] | + | [[Image:1pmi.gif|left|200px]] |
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| - | '''HUMAN RANTES''' | + | {{Structure |
| + | |PDB= 1pmi |SIZE=350|CAPTION= <scene name='initialview01'>1pmi</scene>, resolution 1.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN RANTES''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PMI is a [ | + | 1PMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMI OCA]. |
==Reference== | ==Reference== | ||
| - | The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:[http:// | + | The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8612079 8612079] |
[[Category: Candida albicans]] | [[Category: Candida albicans]] | ||
[[Category: Mannose-6-phosphate isomerase]] | [[Category: Mannose-6-phosphate isomerase]] | ||
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[[Category: aldose-ketose isomerase]] | [[Category: aldose-ketose isomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:26:12 2008'' |
Revision as of 11:26, 20 March 2008
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| , resolution 1.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Mannose-6-phosphate isomerase, with EC number 5.3.1.8 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN RANTES
Overview
Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other.
About this Structure
1PMI is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.
Reference
The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution., Cleasby A, Wonacott A, Skarzynski T, Hubbard RE, Davies GJ, Proudfoot AE, Bernard AR, Payton MA, Wells TN, Nat Struct Biol. 1996 May;3(5):470-9. PMID:8612079
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