2l2o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_2l2o| PDB=2l2o | SCENE= }}
+
==Solution structure of human HSPC280 protein==
-
===Solution structure of human HSPC280 protein===
+
<StructureSection load='2l2o' size='340' side='right' caption='[[2l2o]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
{{ABSTRACT_PUBMED_21082705}}
+
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2l2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2O FirstGlance]. <br>
 +
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C6orf115 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l2o RCSB], [http://www.ebi.ac.uk/pdbsum/2l2o PDBsum]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The human HSPC280 protein belongs to a new family of low molecular weight proteins, which is only present in eukaryotes, and is absent in fungi. The solution structure of HSPC280 was determined using multidimensional NMR spectroscopy. The overall structure consists of three alpha-helices and four antiparallel beta-strands and has a winged helix-like fold. However, HEPC280 is not a typical DNA-binding winged helix protein in that it lacks DNA-binding activity. Unlike most winged-helix proteins, HSPC280 has an unusually long 13-residue (P62-V74) wing 1 loop connecting the beta3 and beta4 strands of the protein. Molecules of HSPC280 have a positively charged surface on one side and a negatively charged surface on the other side of the protein structure. Comparisons with the C-terminal 80-residue domain of proteins in the Abra family reveal a conserved hydrophobic groove in the HSPC280 family, which may allow HSPC280 to interact with other proteins.
-
==About this Structure==
+
Solution structure of the human HSPC280 protein.,Lin J, Zhou T, Wang J Protein Sci. 2011 Jan;20(1):216-23. PMID:21082705<ref>PMID:21082705</ref>
-
[[2l2o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2O OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:021082705</ref><references group="xtra"/><references/>
+
</div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Lin, J.]]
+
[[Category: Lin, J]]
-
[[Category: Wang, J.]]
+
[[Category: Wang, J]]
[[Category: C6orf115]]
[[Category: C6orf115]]
[[Category: Hspc280]]
[[Category: Hspc280]]
[[Category: Unknown function]]
[[Category: Unknown function]]
[[Category: Winged helix]]
[[Category: Winged helix]]

Revision as of 11:51, 18 December 2014

Solution structure of human HSPC280 protein

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l2o"
Personal tools