1pob

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[[Image:1pob.gif|left|200px]]<br /><applet load="1pob" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pob.gif|left|200px]]
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caption="1pob, resolution 2.0&Aring;" />
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'''CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''<br />
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{{Structure
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|PDB= 1pob |SIZE=350|CAPTION= <scene name='initialview01'>1pob</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GEL:1-O-OCTYL-2-HEPTYLPHOSPHONYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>GEL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1POB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=GEL:'>GEL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POB OCA].
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1POB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POB OCA].
==Reference==
==Reference==
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Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2274787 2274787]
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Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2274787 2274787]
[[Category: Naja atra]]
[[Category: Naja atra]]
[[Category: Phospholipase A(2)]]
[[Category: Phospholipase A(2)]]
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[[Category: hydrolase]]
[[Category: hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:26:53 2008''

Revision as of 11:26, 20 March 2008

Image:1pob.gif


PDB ID 1pob

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: and
Activity: Phospholipase A(2), with EC number 3.1.1.4
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE


Overview

The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is stabilized and how the hydrophobic fatty acyl chains of the substrate are accommodated by the enzyme during interfacial catalysis. The critical features that suggest the chemistry of binding and catalysis are the same as those seen in the crystal structure of a similar complex formed with the evolutionarily distant bee-venom PLA2.

About this Structure

1POB is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.

Reference

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:2274787

Page seeded by OCA on Thu Mar 20 13:26:53 2008

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