1pop

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[[Image:1pop.gif|left|200px]]<br /><applet load="1pop" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pop.gif|left|200px]]
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caption="1pop, resolution 2.1&Aring;" />
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'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX'''<br />
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{{Structure
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|PDB= 1pop |SIZE=350|CAPTION= <scene name='initialview01'>1pop</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=MOH:METHANOL'>MOH</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2]
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|GENE=
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}}
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'''X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1POP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=MOH:'>MOH</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Papain Papain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.2 3.4.22.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POP OCA].
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1POP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POP OCA].
==Reference==
==Reference==
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X-ray crystallographic structure of a papain-leupeptin complex., Schroder E, Phillips C, Garman E, Harlos K, Crawford C, FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8416808 8416808]
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X-ray crystallographic structure of a papain-leupeptin complex., Schroder E, Phillips C, Garman E, Harlos K, Crawford C, FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8416808 8416808]
[[Category: Papain]]
[[Category: Papain]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hydrolase(thiol protease)]]
[[Category: hydrolase(thiol protease)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:27:01 2008''

Revision as of 11:27, 20 March 2008

Image:1pop.gif


PDB ID 1pop

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: and
Activity: Papain, with EC number 3.4.22.2
Coordinates: save as pdb, mmCIF, xml



X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX


Overview

The three-dimensional structure of the papain-leupeptin complex has been determined by X-ray crystallography to a resolution of 2.1 A (overall R-factor = 19.8%). The structure indicates that: (i) leupeptin contacts the S subsites of the papain active site and not the S' subsites; (ii) the 'carbonyl' carbon atom of the inhibitor is covalently bound by the Cys-25 sulphur atom of papain and is tetrahedrally coordinated; (iii) the 'carbonyl' oxygen atom of the inhibitor faces the oxyanion hole and makes hydrogen bond contacts with Gln-19 and Cys-25.

About this Structure

1POP is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic structure of a papain-leupeptin complex., Schroder E, Phillips C, Garman E, Harlos K, Crawford C, FEBS Lett. 1993 Jan 2;315(1):38-42. PMID:8416808

Page seeded by OCA on Thu Mar 20 13:27:01 2008

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