2l24
From Proteopedia
(Difference between revisions)
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| - | + | ==Antimicrobial peptide== | |
| - | === | + | <StructureSection load='2l24' size='340' side='right' caption='[[2l24]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2l24]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L24 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l24 RCSB], [http://www.ebi.ac.uk/pdbsum/2l24 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Antimicrobial activity and solution structures of four 13-amino acid peptides derived from the fusion domain of viral hemagglutinin proteins are presented. The results show that carboxyl-terminal amidation is a key factor to switch a viral fusion domain-derived sequence into an antimicrobial peptide. Optimization of amphiphilic balance on the amidated analogue largely improves efficacy and enlarges antimicrobial spectra of these peptides. Our work indicates that viral fusion domains have potential to be engineered into potent antimicrobial peptides. | ||
| - | + | Convergent evolution-guided design of antimicrobial peptides derived from influenza A virus hemagglutinin.,Zhu S, Aumelas A, Gao B J Med Chem. 2011 Feb 24;54(4):1091-5. Epub 2011 Jan 11. PMID:21222457<ref>PMID:21222457</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Aumelas, A | + | == References == |
| - | [[Category: Gao, B | + | <references/> |
| - | [[Category: Zhu, S | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Aumelas, A]] | ||
| + | [[Category: Gao, B]] | ||
| + | [[Category: Zhu, S]] | ||
[[Category: Antimicrobial peptide]] | [[Category: Antimicrobial peptide]] | ||
[[Category: Antimicrobial protein]] | [[Category: Antimicrobial protein]] | ||
[[Category: Design]] | [[Category: Design]] | ||
[[Category: Hemagglutinin]] | [[Category: Hemagglutinin]] | ||
Revision as of 12:08, 18 December 2014
Antimicrobial peptide
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