1poz
From Proteopedia
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| - | [[Image:1poz.jpg|left|200px]] | + | [[Image:1poz.jpg|left|200px]] |
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| - | '''SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44''' | + | {{Structure |
| + | |PDB= 1poz |SIZE=350|CAPTION= <scene name='initialview01'>1poz</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD44 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1POZ is a [ | + | 1POZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1POZ OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44., Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG, Mol Cell. 2004 Feb 27;13(4):483-96. PMID:[http:// | + | Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44., Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG, Mol Cell. 2004 Feb 27;13(4):483-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14992719 14992719] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: link module]] | [[Category: link module]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:27:06 2008'' |
Revision as of 11:27, 20 March 2008
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| Gene: | CD44 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE HYALURONAN BINDING DOMAIN OF HUMAN CD44
Contents |
Overview
Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and tumor metastasis. Regulation of such events is critical and appears to be effected by changes in CD44 N-glycosylation that switch the receptor "on" or "off" under appropriate circumstances. How altered glycosylation influences binding of hyaluronan to the lectin-like Link module in CD44 is unclear, although evidence suggests additional flanking sequences peculiar to CD44 may be involved. Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding domain and a formerly unidentified protein fold. Moreover, the disposition of key N-glycosylation sites reveals how specific sugar chains could alter both the affinity and avidity of CD44 HA binding. Our results provide the necessary structural framework for understanding the diverse functions of CD44 and developing novel therapeutic strategies.
Disease
Known diseases associated with this structure: Blood group, Indian system OMIM:[107269], Fertile eunuch syndrome OMIM:[138850], Hypogonadotropic hypogonadism OMIM:[138850]
About this Structure
1POZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44., Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG, Mol Cell. 2004 Feb 27;13(4):483-96. PMID:14992719
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