1pp5

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[[Image:1pp5.gif|left|200px]]<br /><applet load="1pp5" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pp5.gif|left|200px]]
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caption="1pp5" />
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'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''<br />
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{{Structure
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|PDB= 1pp5 |SIZE=350|CAPTION= <scene name='initialview01'>1pp5</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= MCJA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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}}
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'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1PP5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].
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1PP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].
==Reference==
==Reference==
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Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot., Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH, J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14531661 14531661]
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Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot., Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH, J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14531661 14531661]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protoknot]]
[[Category: protoknot]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:31:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:27:09 2008''

Revision as of 11:27, 20 March 2008

Image:1pp5.gif


PDB ID 1pp5

Drag the structure with the mouse to rotate
Gene: MCJA (Escherichia coli)
Coordinates: save as pdb, mmCIF, xml



Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot


Overview

The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle. Here, we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact is a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through the cyclic segment. MccJ25 is the first example of a lariat protoknot involving a backbone-side chain amide linkage.

About this Structure

1PP5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot., Bayro MJ, Mukhopadhyay J, Swapna GV, Huang JY, Ma LC, Sineva E, Dawson PE, Montelione GT, Ebright RH, J Am Chem Soc. 2003 Oct 15;125(41):12382-3. PMID:14531661

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