1pq1

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[[Image:1pq1.jpg|left|200px]]<br /><applet load="1pq1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1pq1.jpg|left|200px]]
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caption="1pq1, resolution 1.65&Aring;" />
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'''Crystal structure of Bcl-xl/Bim'''<br />
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{{Structure
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|PDB= 1pq1 |SIZE=350|CAPTION= <scene name='initialview01'>1pq1</scene>, resolution 1.65&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= BCL2L1 OR BCL2L OR BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), BCL2L11 OR BIM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Crystal structure of Bcl-xl/Bim'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1PQ1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ1 OCA].
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1PQ1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQ1 OCA].
==Reference==
==Reference==
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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function., Liu X, Dai S, Zhu Y, Marrack P, Kappler JW, Immunity. 2003 Sep;19(3):341-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14499110 14499110]
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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function., Liu X, Dai S, Zhu Y, Marrack P, Kappler JW, Immunity. 2003 Sep;19(3):341-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14499110 14499110]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: bcl-xl/bim]]
[[Category: bcl-xl/bim]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:31:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:27:29 2008''

Revision as of 11:27, 20 March 2008

Image:1pq1.jpg


PDB ID 1pq1

Drag the structure with the mouse to rotate
, resolution 1.65Å
Gene: BCL2L1 OR BCL2L OR BCLX (Mus musculus), BCL2L11 OR BIM (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of Bcl-xl/Bim


Overview

After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fragment of Bim indicates that the structure of Bim is very different from proteins with a Bcl-2-like fold and may leave the BH3 region of Bim constitutively exposed. Based on the structural homology between Bcl-x(L) and Bax, we predicted that binding of Bim to Bax would require displacement of the Bax penultimate alpha helix. Consistent with this prediction, truncation of this short helix was required for Bim/Bax interaction and led to spontaneous activation of Bax. Our results suggest a way in which both Bim and Bax/Bak might be required for activated T cell apoptosis.

About this Structure

1PQ1 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function., Liu X, Dai S, Zhu Y, Marrack P, Kappler JW, Immunity. 2003 Sep;19(3):341-52. PMID:14499110

Page seeded by OCA on Thu Mar 20 13:27:29 2008

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