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2rrr

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{{STRUCTURE_2rrr| PDB=2rrr | SCENE= }}
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==DNA oligomer containing ethylene cross-linked cyclic 2'-deoxyuridylate dimer==
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===DNA oligomer containing ethylene cross-linked cyclic 2'-deoxyuridylate dimer===
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<StructureSection load='2rrr' size='340' side='right' caption='[[2rrr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_21443191}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2rrr]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RRR FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rrq|2rrq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rrr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rrr RCSB], [http://www.ebi.ac.uk/pdbsum/2rrr PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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High Mobility Group Box 1 (HMGB1) protein, a potential therapeutic target, binds bent DNAs structure-specifically. Here we report on a crucial structural feature of the bent DNA required for strong binding to HMGB1. NMR structures of two bent DNA oligomers, only one of which binds strongly to HMGB1, revealed that the presence of a pocket structure on the minor groove is crucial for strong binding through penetration of a phenylalanine residue.
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==About this Structure==
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Structural feature of bent DNA recognized by HMGB1.,Furuita K, Murata S, Jee JG, Ichikawa S, Matsuda A, Kojima C J Am Chem Soc. 2011 Apr 20;133(15):5788-90. Epub 2011 Mar 28. PMID:21443191<ref>PMID:21443191</ref>
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[[2rrr]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRR OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021443191</ref><references group="xtra"/><references/>
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</div>
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[[Category: Furuita, K.]]
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== References ==
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[[Category: Ichikawa, S.]]
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<references/>
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[[Category: Jee, J G.]]
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__TOC__
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[[Category: Kojima, C.]]
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</StructureSection>
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[[Category: Matsuda, A.]]
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[[Category: Furuita, K]]
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[[Category: Murata, S.]]
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[[Category: Ichikawa, S]]
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[[Category: Jee, J G]]
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[[Category: Kojima, C]]
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[[Category: Matsuda, A]]
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[[Category: Murata, S]]
[[Category: Bent dna]]
[[Category: Bent dna]]
[[Category: Deoxyuridylate]]
[[Category: Deoxyuridylate]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Nucleic acid]]
[[Category: Nucleic acid]]

Revision as of 12:19, 18 December 2014

DNA oligomer containing ethylene cross-linked cyclic 2'-deoxyuridylate dimer

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