2w18
From Proteopedia
(Difference between revisions)
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| - | + | ==CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF HUMAN PALB2== | |
| - | + | <StructureSection load='2w18' size='340' side='right' caption='[[2w18]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2w18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W18 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w18 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w18 RCSB], [http://www.ebi.ac.uk/pdbsum/2w18 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The breast cancer 2, early onset protein (BRCA2) is central to the repair of DNA damage by homologous recombination. BRCA2 recruits the recombinase RAD51 to sites of damage, regulates its assembly into nucleoprotein filaments and thereby promotes homologous recombination. Localization of BRCA2 to nuclear foci requires its association with the partner and localizer of BRCA2 (PALB2), mutations in which are associated with cancer predisposition, as well as subtype N of Fanconi anaemia. We have determined the structure of the PALB2 carboxy-terminal beta-propeller domain in complex with a BRCA2 peptide. The structure shows the molecular determinants of this important protein-protein interaction and explains the effects of both cancer-associated truncating mutants in PALB2 and missense mutations in the amino-terminal region of BRCA2. | ||
| - | + | Structural basis for recruitment of BRCA2 by PALB2.,Oliver AW, Swift S, Lord CJ, Ashworth A, Pearl LH EMBO Rep. 2009 Sep;10(9):990-6. Epub 2009 Jul 17. PMID:19609323<ref>PMID:19609323</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Oliver, A W | + | [[Category: Oliver, A W]] |
| - | [[Category: Pearl, L H | + | [[Category: Pearl, L H]] |
[[Category: Beta-propeller]] | [[Category: Beta-propeller]] | ||
[[Category: Fanc-n]] | [[Category: Fanc-n]] | ||
Revision as of 12:30, 18 December 2014
CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF HUMAN PALB2
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