1ps1
From Proteopedia
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| - | [[Image:1ps1.jpg|left|200px]] | + | [[Image:1ps1.jpg|left|200px]] |
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| - | '''PENTALENENE SYNTHASE''' | + | {{Structure |
| + | |PDB= 1ps1 |SIZE=350|CAPTION= <scene name='initialview01'>1ps1</scene>, resolution 2.60Å | ||
| + | |SITE= <scene name='pdbsite=AR1:Aspartate-Rich+Region,+Monomer+A'>AR1</scene> and <scene name='pdbsite=AR2:Aspartate-Rich+Region,+Monomer+B'>AR2</scene> | ||
| + | |LIGAND= <scene name='pdbligand=PBM:TRIMETHYL LEAD ION'>PBM</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_4.2.3.7 Transferred entry: 4.2.3.7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.5 4.6.1.5] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''PENTALENENE SYNTHASE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PS1 is a [ | + | 1PS1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PS1 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:[http:// | + | Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9295272 9295272] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces sp.]] | [[Category: Streptomyces sp.]] | ||
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[[Category: sesquiterpene cyclase]] | [[Category: sesquiterpene cyclase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:28:16 2008'' |
Revision as of 11:28, 20 March 2008
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| , resolution 2.60Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Activity: | Transferred entry: 4.2.3.7, with EC number 4.6.1.5 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PENTALENENE SYNTHASE
Overview
The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pentalenene. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. The core active site structure of the enzyme may be preserved among the greater family of terpenoid synthases, possibly implying divergence from a common ancestral synthase to satisfy biological requirements for increasingly diverse natural products.
About this Structure
1PS1 is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.
Reference
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology., Lesburg CA, Zhai G, Cane DE, Christianson DW, Science. 1997 Sep 19;277(5333):1820-4. PMID:9295272
Page seeded by OCA on Thu Mar 20 13:28:16 2008
