1psi
From Proteopedia
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| - | [[Image:1psi.gif|left|200px]] | + | [[Image:1psi.gif|left|200px]] |
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| - | '''INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU''' | + | {{Structure |
| + | |PDB= 1psi |SIZE=350|CAPTION= <scene name='initialview01'>1psi</scene>, resolution 2.92Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SCC:THIOETHYL GROUP'>SCC</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= ALPHA-1-ANTITRYPSIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PSI is a [ | + | 1PSI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1PSI with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb53_1.html Serpins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSI OCA]. |
==Reference== | ==Reference== | ||
| - | Inhibitory conformation of the reactive loop of alpha 1-antitrypsin., Elliott PR, Lomas DA, Carrell RW, Abrahams JP, Nat Struct Biol. 1996 Aug;3(8):676-81. PMID:[http:// | + | Inhibitory conformation of the reactive loop of alpha 1-antitrypsin., Elliott PR, Lomas DA, Carrell RW, Abrahams JP, Nat Struct Biol. 1996 Aug;3(8):676-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8756325 8756325] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Serpins]] | [[Category: Serpins]] | ||
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[[Category: signal]] | [[Category: signal]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:28:25 2008'' |
Revision as of 11:28, 20 March 2008
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| , resolution 2.92Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | ALPHA-1-ANTITRYPSIN (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
INTACT RECOMBINED ALPHA1-ANTITRYPSIN MUTANT PHE 51 TO LEU
Contents |
Overview
The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matching that found in all other families of serine proteinase inhibitors. This unexpected finding in the absence of loop insertion into the body of the molecule favours a two-stage mechanism of inhibition and provides a model for the heparin activation of antithrombin. The beta-pleated strand conformation of the loop also accounts for the polymerization of the serpins in disease and for their association with other beta-sheet structures, most notably the beta-amyloid of Alzheimer's disease.
Disease
Known diseases associated with this structure: Emphysema OMIM:[107400], Emphysema-cirrhosis OMIM:[107400], Hemorrhagic diathesis due to antithrombin Pittsburgh OMIM:[107400], Pulmonary disease, chronic obstructive, susceptibility to OMIM:[107400]
About this Structure
1PSI is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1PSI with [Serpins]. Full crystallographic information is available from OCA.
Reference
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin., Elliott PR, Lomas DA, Carrell RW, Abrahams JP, Nat Struct Biol. 1996 Aug;3(8):676-81. PMID:8756325
Page seeded by OCA on Thu Mar 20 13:28:25 2008
