2mbj
From Proteopedia
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| - | + | ==Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution)== | |
| - | + | <StructureSection load='2mbj' size='340' side='right' caption='[[2mbj]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2mbj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[1kf1|1kf1]], [[2jsm|2jsm]], [[2jsl|2jsl]], [[2kf8|2kf8]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbj RCSB], [http://www.ebi.ac.uk/pdbsum/2mbj PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Single-stranded DNA overhangs at the ends of human telomeric repeats are capable of adopting four-stranded G-quadruplex structures, which could serve as potential anticancer targets. Out of the five reported intramolecular human telomeric G-quadruplex structures, four were formed in the presence of K+ ions and only one in the presence of Na+ ions, leading often to a perception that this structural polymorphism occurs exclusively in the presence of K+ but not Na+. Here we present the structure of a new antiparallel (2+2) G-quadruplex formed by a derivative of a 27-nt human telomeric sequence in Na+ solution, which comprises a novel core arrangement distinct from the known topologies. This structure complements the previously elucidated basket-type human telomeric G-quadruplex to serve as reference structures in Na+-containing environment. These structures, together with the coexistence of other conformations in Na+ solution as observed by nuclear magnetic resonance spectroscopy, establish the polymorphic nature of human telomeric repeats beyond the influence of K+ ions. | ||
| - | + | Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity.,Lim KW, Ng VC, Martin-Pintado N, Heddi B, Phan AT Nucleic Acids Res. 2013 Sep 2. PMID:23999095<ref>PMID:23999095</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Heddi, B | + | == References == |
| - | [[Category: Lim, K W | + | <references/> |
| - | [[Category: Martin-Pintado, N | + | __TOC__ |
| - | [[Category: Ng, V C.M | + | </StructureSection> |
| - | [[Category: Phan, A T | + | [[Category: Heddi, B]] |
| + | [[Category: Lim, K W]] | ||
| + | [[Category: Martin-Pintado, N]] | ||
| + | [[Category: Ng, V C.M]] | ||
| + | [[Category: Phan, A T]] | ||
[[Category: Anticancer target]] | [[Category: Anticancer target]] | ||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: G-quadruplex]] | [[Category: G-quadruplex]] | ||
[[Category: Human telomere]] | [[Category: Human telomere]] | ||
Revision as of 12:37, 18 December 2014
Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution)
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