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1ptq
From Proteopedia
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| - | [[Image:1ptq.gif|left|200px]] | + | [[Image:1ptq.gif|left|200px]] |
| - | + | ||
| - | '''PROTEIN KINASE C DELTA CYS2 DOMAIN''' | + | {{Structure |
| + | |PDB= 1ptq |SIZE=350|CAPTION= <scene name='initialview01'>1ptq</scene>, resolution 1.95Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''PROTEIN KINASE C DELTA CYS2 DOMAIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1PTQ is a [ | + | 1PTQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PTQ OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:[http:// | + | Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7781068 7781068] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:28:49 2008'' |
Revision as of 11:28, 20 March 2008
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| , resolution 1.95Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PROTEIN KINASE C DELTA CYS2 DOMAIN
Overview
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.
About this Structure
1PTQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068
Page seeded by OCA on Thu Mar 20 13:28:49 2008
