2m7h

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{{STRUCTURE_2m7h| PDB=2m7h | SCENE= }}
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==The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition==
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===The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition===
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<StructureSection load='2m7h' size='340' side='right' caption='[[2m7h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M7H FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/VM2RH_CALRH VM2RH_CALRH]] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pji|2pji]], [[2m7f|2m7f]], [[2m75|2m75]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8717 Calloselasma rhodostoma])</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m7h RCSB], [http://www.ebi.ac.uk/pdbsum/2m7h PDBsum]</span></td></tr>
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[[2m7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7H OCA].
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</table>
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__TOC__
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</StructureSection>
[[Category: Calloselasma rhodostoma]]
[[Category: Calloselasma rhodostoma]]
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[[Category: Chang, Y.]]
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[[Category: Chang, Y]]
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[[Category: Chuang, W.]]
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[[Category: Chuang, W]]
[[Category: C-terminal region mutation]]
[[Category: C-terminal region mutation]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 12:45, 18 December 2014

The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Integrin alpha-IIb beta-3 Recognition

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