1mpv

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{{STRUCTURE_1mpv| PDB=1mpv | SCENE= }}
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==Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide==
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===Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide===
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<StructureSection load='1mpv' size='340' side='right' caption='[[1mpv]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{ABSTRACT_PUBMED_12387744}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mpv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MPV FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mpv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mpv RCSB], [http://www.ebi.ac.uk/pdbsum/1mpv PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref> <ref>PMID:12387744</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-kappaB2/p100 to p52. NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells. Furthermore, wild-type mice injected with BAFF-neutralizing BR3-Fc protein showed reduced basal NF-kappaB2 activation. BR3-Fc treatment of NZB/WF1 mice, which develop a fatal lupus-like syndrome, inhibited NF-kappaB2 processing and attenuated the disease process. Since inhibiting the BR3-BAFF interaction has therapeutic ramifications, the ligand binding interface of BR3 was investigated and found to reside within a 26 residue core domain. When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF.
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==Disease==
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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.,Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM Immunity. 2002 Oct;17(4):515-24. PMID:12387744<ref>PMID:12387744</ref>
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[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref>
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==Function==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.<ref>PMID:11591325</ref><ref>PMID:12387744</ref>
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</div>
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== References ==
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==About this Structure==
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<references/>
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[[1mpv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPV OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Cochran, A G]]
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<references group="xtra"/><references/>
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[[Category: Dixit, V M]]
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[[Category: Cochran, A G.]]
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[[Category: French, D M]]
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[[Category: Dixit, V M.]]
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[[Category: Gordon, N C]]
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[[Category: French, D M.]]
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[[Category: Grewal, I S]]
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[[Category: Gordon, N C.]]
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[[Category: Kayagaki, N]]
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[[Category: Grewal, I S.]]
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[[Category: Lee, W]]
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[[Category: Kayagaki, N.]]
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[[Category: Seshasayee, D]]
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[[Category: Lee, W.]]
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[[Category: Starovasnik, M A]]
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[[Category: Seshasayee, D.]]
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[[Category: Wang, H]]
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[[Category: Starovasnik, M A.]]
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[[Category: Yan, M]]
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[[Category: Wang, H.]]
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[[Category: Yin, J]]
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[[Category: Yan, M.]]
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[[Category: Yin, J.]]
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[[Category: Beta-hairpin]]
[[Category: Beta-hairpin]]
[[Category: Protein binding]]
[[Category: Protein binding]]

Revision as of 12:47, 18 December 2014

Structure of bhpBR3, the BAFF-binding loop of BR3 embedded in a beta-hairpin peptide

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