3g7c

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{{STRUCTURE_3g7c| PDB=3g7c | SCENE= }}
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==Structure of the Phosphorylation Mimetic of Occludin C-term Tail==
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===Structure of the Phosphorylation Mimetic of Occludin C-term Tail===
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<StructureSection load='3g7c' size='340' side='right' caption='[[3g7c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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{{ABSTRACT_PUBMED_19125584}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3G7C FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wpa|1wpa]], [[1xaw|1xaw]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OCLN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3g7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g7c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3g7c RCSB], [http://www.ebi.ac.uk/pdbsum/3g7c PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[http://omim.org/entry/251290 251290]]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/3g7c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The molecular function of occludin, an integral membrane component of tight junctions, remains unclear. VEGF-induced phosphorylation sites were mapped on occludin by combining MS data analysis with bioinformatics. In vivo phosphorylation of Ser490 was validated and protein interaction studies combined with crystal structure analysis suggest that Ser490 phosphorylation attenuates the interaction between occludin and ZO-1. This study demonstrates that combining MS data and bioinformatics can successfully identify novel phosphorylation sites from limiting samples.
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==Disease==
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Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach.,Sundstrom JM, Tash BR, Murakami T, Flanagan JM, Bewley MC, Stanley BA, Gonsar KB, Antonetti DA J Proteome Res. 2009 Feb;8(2):808-17. PMID:19125584<ref>PMID:19125584</ref>
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[http://omim.org/entry/251290 251290]]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
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==Function==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[http://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN]] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
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</div>
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== References ==
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==About this Structure==
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<references/>
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[[3g7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G7C OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019125584</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Antonetii, D A.]]
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[[Category: Antonetii, D A]]
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[[Category: Bewley, M C.]]
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[[Category: Bewley, M C]]
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[[Category: Flanagan, J M.]]
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[[Category: Flanagan, J M]]
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[[Category: Murakami, T.]]
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[[Category: Murakami, T]]
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[[Category: Sundstrom, J M.]]
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[[Category: Sundstrom, J M]]
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[[Category: Tash, B R.]]
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[[Category: Tash, B R]]
[[Category: Adhesion]]
[[Category: Adhesion]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]

Revision as of 13:14, 18 December 2014

Structure of the Phosphorylation Mimetic of Occludin C-term Tail

3g7c, resolution 2.00Å

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