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3fb2
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | |
| - | + | <StructureSection load='3fb2' size='340' side='right' caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FB2 FirstGlance]. <br> |
| - | [[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u5p|1u5p]]</td></tr> | |
| - | ==Function== | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [http://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Defects in SPTAN1 are the cause of epileptic encephalopathy early infantile type 5 (EIEE5) [MIM:[http://omim.org/entry/613477 613477]]. EIEE5 is a disorder characterized by seizures associated with hypsarrhythmia profound mental retardation with lack of visual attention and speech development, as well as spastic quadriplegia.<ref>PMID:20493457</ref> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | [[http://www.uniprot.org/uniprot/SPTA2_HUMAN SPTA2_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. | ||
| - | |||
| - | ==About this Structure== | ||
| - | [[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. | ||
==See Also== | ==See Also== | ||
*[[Spectrin|Spectrin]] | *[[Spectrin|Spectrin]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Acton, T B | + | [[Category: Acton, T B]] |
| - | [[Category: Ciccosanti, C | + | [[Category: Ciccosanti, C]] |
| - | [[Category: Foote, E L | + | [[Category: Foote, E L]] |
| - | [[Category: Hunt, J F | + | [[Category: Hunt, J F]] |
| - | [[Category: Janjua, H | + | [[Category: Janjua, H]] |
| - | [[Category: Montelione, G T | + | [[Category: Montelione, G T]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Seetharaman, J | + | [[Category: Seetharaman, J]] |
| - | [[Category: Shastry, R | + | [[Category: Shastry, R]] |
| - | [[Category: Su, M | + | [[Category: Su, M]] |
| - | [[Category: Tong, L | + | [[Category: Tong, L]] |
| - | [[Category: Vorobiev, S M | + | [[Category: Vorobiev, S M]] |
| - | [[Category: Xiao, R | + | [[Category: Xiao, R]] |
[[Category: Actin capping]] | [[Category: Actin capping]] | ||
[[Category: Actin-binding]] | [[Category: Actin-binding]] | ||
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[[Category: Nesg]] | [[Category: Nesg]] | ||
[[Category: Non-erythroid alpha chain alpha-ii spectrin]] | [[Category: Non-erythroid alpha chain alpha-ii spectrin]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
[[Category: Spectrin alpha chain]] | [[Category: Spectrin alpha chain]] | ||
[[Category: Spta2_human]] | [[Category: Spta2_human]] | ||
[[Category: Sptan1]] | [[Category: Sptan1]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 13:38, 18 December 2014
Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.
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Categories: Homo sapiens | Acton, T B | Ciccosanti, C | Foote, E L | Hunt, J F | Janjua, H | Montelione, G T | Structural genomic | Seetharaman, J | Shastry, R | Su, M | Tong, L | Vorobiev, S M | Xiao, R | Actin capping | Actin-binding | Brain spectrin | Calmodulin-binding | Cytoskeleton | Fordrin alpha chain | Hr5563a | Nesg | Non-erythroid alpha chain alpha-ii spectrin | Phosphoprotein | PSI, Protein structure initiative | Sh3 domain | Spectrin alpha chain | Spta2 human | Sptan1 | Structural protein
