1q0y

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[[Image:1q0y.gif|left|200px]]<br /><applet load="1q0y" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1q0y.gif|left|200px]]
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caption="1q0y, resolution 2.00&Aring;" />
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'''Anti-Morphine Antibody 9B1 Complexed with Morphine'''<br />
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{{Structure
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|PDB= 1q0y |SIZE=350|CAPTION= <scene name='initialview01'>1q0y</scene>, resolution 2.00&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MOI:(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL'>MOI</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Anti-Morphine Antibody 9B1 Complexed with Morphine'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Q0Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=MOI:'>MOI</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0Y OCA].
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1Q0Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q0Y OCA].
==Reference==
==Reference==
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Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine., Pozharski E, Wilson MA, Hewagama A, Shanafelt AB, Petsko G, Ringe D, J Mol Biol. 2004 Mar 26;337(3):691-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15019787 15019787]
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Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine., Pozharski E, Wilson MA, Hewagama A, Shanafelt AB, Petsko G, Ringe D, J Mol Biol. 2004 Mar 26;337(3):691-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15019787 15019787]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: fab]]
[[Category: fab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:34:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:31:35 2008''

Revision as of 11:31, 20 March 2008

Image:1q0y.gif


PDB ID 1q0y

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Anti-Morphine Antibody 9B1 Complexed with Morphine


Overview

The crystal structures of an anti-morphine antibody 9B1 (to 1.6A resolution) and its complex with morphine (to 2.0 A resolution) are reported. The morphine-binding site is described as a shallow depression on the protein surface, an unusual topology for a high-affinity ( Ka approximately 10(9) M(-1)) antibody against a small antigen. The polar part of the ligand is exposed to solvent, and the cationic nitrogen atom of the morphine molecule is anchored at the bottom of the binding site by a salt-bridge to a glutamate side-chain. Additional affinity is provided by a double cation-pi interaction with two tryptophan residues. Comparison of the morphine complex with the structure of the free Fab shows that a domain closure occurs upon binding of the ligand.

About this Structure

1Q0Y is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Anchoring a cationic ligand: the structure of the Fab fragment of the anti-morphine antibody 9B1 and its complex with morphine., Pozharski E, Wilson MA, Hewagama A, Shanafelt AB, Petsko G, Ringe D, J Mol Biol. 2004 Mar 26;337(3):691-7. PMID:15019787

Page seeded by OCA on Thu Mar 20 13:31:35 2008

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