3ajy
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal Structure of Ancestral Congerin Con-anc== | |
| - | + | <StructureSection load='3ajy' size='340' side='right' caption='[[3ajy]], [[Resolution|resolution]] 2.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[3ajy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AJY FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1is3|1is3]], [[1is4|1is4]], [[1is5|1is5]], [[1is6|1is6]], [[1c1l|1c1l]], [[1c1f|1c1f]], [[3ajz|3ajz]], [[3ak0|3ak0]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ajy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ajy RCSB], [http://www.ebi.ac.uk/pdbsum/3ajy PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ancestral structures of fish galectins (congerins) were determined. The extant isoforms I and II of congerin are the components of a fish biological defense system and have rapidly differentiated under natural selection pressure, by which congerin I has experienced a protein-fold evolution. The dimer structure of the ancestral congerin demonstrated intermediate features of the extant isoforms. The protein-fold evolution was not observed in the ancestral structure, indicating it specifically occurred in congerin I lineage. Details of hydrogen bonding pattern at the dimer interface and the carbohydrate-binding site of the ancestor were different from the current proteins. The differences implied these proteins were under selection pressure for stabilizing dimer structure and differentiation in carbohydrate specificity. The ancestor had rather low cytotoxic activity than offspring, indicating selection was made to enhance this activity of congerins. Combined with functional analyses, the structure revealed atomic details of the differentiation process of the proteins. | ||
| - | + | Tracing protein evolution through ancestral structures of fish galectin.,Konno A, Kitagawa A, Watanabe M, Ogawa T, Shirai T Structure. 2011 May 11;19(5):711-21. PMID:21565705<ref>PMID:21565705</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Kitagawa, A | + | == References == |
| - | [[Category: Konno, A | + | <references/> |
| - | [[Category: Ogawa, T | + | __TOC__ |
| - | [[Category: Shirai, T | + | </StructureSection> |
| - | [[Category: Watanabe, M | + | [[Category: Kitagawa, A]] |
| + | [[Category: Konno, A]] | ||
| + | [[Category: Ogawa, T]] | ||
| + | [[Category: Shirai, T]] | ||
| + | [[Category: Watanabe, M]] | ||
[[Category: Ancestral protein]] | [[Category: Ancestral protein]] | ||
[[Category: Galectin]] | [[Category: Galectin]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 14:05, 18 December 2014
Crystal Structure of Ancestral Congerin Con-anc
| |||||||||||
