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2y96

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{{STRUCTURE_2y96| PDB=2y96 | SCENE= }}
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==STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 27==
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===STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 27===
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<StructureSection load='2y96' size='340' side='right' caption='[[2y96]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21543850}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y96 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y96 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y96 RCSB], [http://www.ebi.ac.uk/pdbsum/2y96 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 A resolution are presented.
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==About this Structure==
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Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.,Lountos GT, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):471-9. Epub 2011, Apr 16. PMID:21543850<ref>PMID:21543850</ref>
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[[2y96]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y96 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021543850</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lountos, G T.]]
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[[Category: Lountos, G T]]
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[[Category: Tropea, J E.]]
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[[Category: Tropea, J E]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh, D S]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 14:14, 18 December 2014

STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 27

2y96, resolution 2.38Å

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