2y96

Publication Abstract from PubMed

There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 A resolution are presented.

Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.,Lountos GT, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):471-9. Epub 2011, Apr 16. PMID:21543850^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.