3dyd

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{{STRUCTURE_3dyd| PDB=3dyd | SCENE= }}
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==Human Tyrosine Aminotransferase==
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===Human Tyrosine Aminotransferase===
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<StructureSection load='3dyd' size='340' side='right' caption='[[3dyd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DYD FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[http://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TAT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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==Function==
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine_transaminase Tyrosine transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5 2.6.1.5] </span></td></tr>
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[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref><ref>PMID:16640556</ref>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dyd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dyd RCSB], [http://www.ebi.ac.uk/pdbsum/3dyd PDBsum]</span></td></tr>
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</table>
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==About this Structure==
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== Disease ==
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[[3dyd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DYD OCA].
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[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:[http://omim.org/entry/276600 276600]]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.<ref>PMID:1357662</ref>
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== Function ==
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==Reference==
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[[http://www.uniprot.org/uniprot/ATTY_HUMAN ATTY_HUMAN]] Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.<ref>PMID:7999802</ref> <ref>PMID:16640556</ref>
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<references group="xtra"/><references/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/3dyd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Tyrosine transaminase]]
[[Category: Tyrosine transaminase]]
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[[Category: Andersson, J.]]
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[[Category: Andersson, J]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Berg, S Van Den.]]
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[[Category: Berg, S Van Den]]
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[[Category: Berglund, H.]]
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[[Category: Berglund, H]]
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[[Category: Collins, R.]]
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[[Category: Collins, R]]
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[[Category: Dahlgren, L G.]]
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[[Category: Dahlgren, L G]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Flodin, S.]]
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[[Category: Flodin, S]]
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[[Category: Flores, A.]]
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[[Category: Flores, A]]
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[[Category: Graslund, S.]]
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[[Category: Graslund, S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hammarstrom, M]]
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[[Category: Johansson, A.]]
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[[Category: Johansson, A]]
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[[Category: Johansson, I.]]
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[[Category: Johansson, I]]
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[[Category: Karlberg, T.]]
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[[Category: Karlberg, T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotenyova, T]]
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[[Category: Lehtio, L.]]
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[[Category: Lehtio, L]]
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[[Category: Moche, M.]]
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[[Category: Moche, M]]
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[[Category: Nilsson, M E.]]
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[[Category: Nilsson, M E]]
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[[Category: Nordlund, P.]]
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[[Category: Nordlund, P]]
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[[Category: Nyman, T.]]
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[[Category: Nyman, T]]
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[[Category: Olesen, K.]]
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[[Category: Olesen, K]]
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[[Category: Persson, C.]]
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[[Category: Persson, C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Sagemark, J.]]
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[[Category: Sagemark, J]]
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[[Category: Schuler, H.]]
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[[Category: Schuler, H]]
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[[Category: Thorsell, A G.]]
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[[Category: Thorsell, A G]]
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[[Category: Tresaugues, L.]]
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[[Category: Tresaugues, L]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Welin, M.]]
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[[Category: Welin, M]]
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[[Category: Wikstrom, M.]]
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[[Category: Wikstrom, M]]
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[[Category: Wisniewska, M.]]
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[[Category: Wisniewska, M]]
[[Category: Aminotransferase]]
[[Category: Aminotransferase]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine]]
[[Category: Tyrosine]]
[[Category: Tyrosine catabolism]]
[[Category: Tyrosine catabolism]]

Revision as of 14:24, 18 December 2014

Human Tyrosine Aminotransferase

3dyd, resolution 2.30Å

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