2yna

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{{STRUCTURE_2yna| PDB=2yna | SCENE= }}
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==Crystal structure of the main protease of coronavirus HKU4==
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===Crystal structure of the main protease of coronavirus HKU4===
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<StructureSection load='2yna' size='340' side='right' caption='[[2yna]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2yna]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tylonycteris_bat_coronavirus_hku4 Tylonycteris bat coronavirus hku4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YNA FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/R1A_BCHK4 R1A_BCHK4]] The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity). The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity). Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity). Nsp9 is a ssRNA-binding protein (By similarity). Non-structural protein 1: binds to the 40S ribosomal subunit and inhibits host translation. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response (By similarity).
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ynb|2ynb]]</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yna OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yna RCSB], [http://www.ebi.ac.uk/pdbsum/2yna PDBsum]</span></td></tr>
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[[2yna]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tylonycteris_bat_coronavirus_hku4 Tylonycteris bat coronavirus hku4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YNA OCA].
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</table>
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__TOC__
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</StructureSection>
[[Category: Tylonycteris bat coronavirus hku4]]
[[Category: Tylonycteris bat coronavirus hku4]]
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[[Category: Hilgenfeld, R.]]
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[[Category: Hilgenfeld, R]]
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[[Category: Ma, Q.]]
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[[Category: Ma, Q]]
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[[Category: Xiao, Y.]]
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[[Category: Xiao, Y]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Sar]]
[[Category: Sar]]

Revision as of 14:24, 18 December 2014

Crystal structure of the main protease of coronavirus HKU4

2yna, resolution 1.50Å

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